![](/images/graphics-bg.png)
Immunogenic Cell Death: Can It Be Exploited in PhotoDynamic Therapy for Cancer?
Joint Authors
Dini, Luciana
Panzarini, Elisa
Inguscio, Valentina
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Immunogenic Cell Death (ICD) could represent the keystone in cancer management since tumor cell death induction is crucial as well as the control of cancer cells revival after neoplastic treatment.
In this context, the immune system plays a fundamental role.
The concept of Damage-Associated Molecular Patterns (DAMPs) has been proposed to explain the immunogenic potential of stressed or dying/dead cells.
ICD relies on DAMPs released by or exposed on dying cells.
Once released, DAMPs are sensed by immune cells, in particular Dendritic Cells (DCs), acting as activators of Antigen-Presenting Cells (APCs), that in turn stimulate both innate and adaptive immunity.
On the other hand, by exposing DAMPs, dying cancer cells change their surface composition, recently indicated as vital for the stimulation of the host immune system and the control of residual ill cells.
It is well established that PhotoDynamic Therapy (PDT) for cancer treatment ignites the immune system to elicit a specific antitumor immunity, probably linked to its ability in inducing exposure/release of certain DAMPs, as recently suggested.
In the present paper, we discuss the DAMPs associated with PDT and their role in the crossroad between cancer cell death and immunogenicity in PDT.
American Psychological Association (APA)
Panzarini, Elisa& Inguscio, Valentina& Dini, Luciana. 2012. Immunogenic Cell Death: Can It Be Exploited in PhotoDynamic Therapy for Cancer?. BioMed Research International،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-1004419
Modern Language Association (MLA)
Panzarini, Elisa…[et al.]. Immunogenic Cell Death: Can It Be Exploited in PhotoDynamic Therapy for Cancer?. BioMed Research International No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-1004419
American Medical Association (AMA)
Panzarini, Elisa& Inguscio, Valentina& Dini, Luciana. Immunogenic Cell Death: Can It Be Exploited in PhotoDynamic Therapy for Cancer?. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-1004419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004419