Detection of AntiphosphatidylserineProthrombin Antibodies and Their Potential Diagnostic Value
Joint Authors
Kveder, Tanja
Ambrožič, Aleš
Čučnik, Saša
Žigon, Polona
Sodin-Semrl, Snezna
Rozman, Blaž
Božič, Borut
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Antiprothrombin antibodies, measured with phosphatidylserine/prothrombin complex (aPS/PT) ELISA, have been reported to be associated with antiphospholipid syndrome (APS).
They are currently being evaluated as a potential classification criterion for this autoimmune disease, characterized by thromboses and obstetric complications.
Given the present lack of clinically useful tests for the accurate diagnosis of APS, we aimed to evaluate in-house and commercial assays for determination of aPS/PT as a potential serological marker for APS.
We screened 156 patients with systemic autoimmune diseases for antibodies against PS/PT, β2-glycoprotein I, cardiolipin and for lupus anticoagulant activity.
We demonstrated a high degree of concordance between the concentrations of aPS/PT measured with the in-house and commercial assays.
Both assays performed comparably relating to the clinical manifestations of APS, such as arterial and venous thromboses and obstetric complications.
IgG aPS/PT represented the strongest independent risk factor for the presence of obstetric complications, among all tested aPL.
Both IgG and IgM aPS/PT were associated with venous thrombosis, but not with arterial thrombosis.
Most importantly, the association between the presence of IgG/IgM aPS/PT and lupus anticoagulant activity was highly significant.
Taken together, aPS/PT antibodies detected with the in-house or commercial ELISA represent a promising serological marker for APS and its subsets.
American Psychological Association (APA)
Žigon, Polona& Čučnik, Saša& Ambrožič, Aleš& Kveder, Tanja& Sodin-Semrl, Snezna& Rozman, Blaž…[et al.]. 2013. Detection of AntiphosphatidylserineProthrombin Antibodies and Their Potential Diagnostic Value. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006895
Modern Language Association (MLA)
Žigon, Polona…[et al.]. Detection of AntiphosphatidylserineProthrombin Antibodies and Their Potential Diagnostic Value. Journal of Immunology Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1006895
American Medical Association (AMA)
Žigon, Polona& Čučnik, Saša& Ambrožič, Aleš& Kveder, Tanja& Sodin-Semrl, Snezna& Rozman, Blaž…[et al.]. Detection of AntiphosphatidylserineProthrombin Antibodies and Their Potential Diagnostic Value. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006895