Elastin-Coated Biodegradable Photopolymer Scaffolds for Tissue Engineering Applications
Joint Authors
Barenghi, Rossella
Beke, Szabolcs
Romano, Ilaria
Gavazzo, Paola
Farkas, Balázs
Vassalli, Massimo
Brandi, Fernando
Scaglione, Silvia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
One of the main open issues in modern vascular surgery is the nonbiodegradability of implants used for stent interventions, which can lead to small caliber-related thrombosis and neointimal hyperplasia.
Some new, resorbable polymeric materials have been proposed to substitute traditional stainless-steel stents, but so far they were affected by poor mechanical properties and low biocompatibility.
In this respect, a new material, polypropylene fumarate (PPF), may be considered as a promising candidate to implement the development of next generation stents, due to its complete biodegradability, and excellent mechanical properties and the ease to be precisely patterned.
Besides all these benefits, PPF has not been tested yet for vascular prosthesis, mainly because it proved to be almost inert, while the ability to elicit a specific biological function would be of paramount importance in such critical surgery applications.
Here, we propose a biomimetic functionalization process, aimed at obtaining specific bioactivation and thus improved cell-polymer interaction.
Porous PPF-based scaffolds produced by deep-UV photocuring were coated by elastin and the functionalized scaffolds were extensively characterized, revealing a stable bound between the protein and the polymer surface.
Both 3T3 and HUVEC cell lines were used for in vitro tests displaying an enhancement of cells adhesion and proliferation on the functionalized scaffolds.
American Psychological Association (APA)
Barenghi, Rossella& Beke, Szabolcs& Romano, Ilaria& Gavazzo, Paola& Farkas, Balázs& Vassalli, Massimo…[et al.]. 2014. Elastin-Coated Biodegradable Photopolymer Scaffolds for Tissue Engineering Applications. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016406
Modern Language Association (MLA)
Barenghi, Rossella…[et al.]. Elastin-Coated Biodegradable Photopolymer Scaffolds for Tissue Engineering Applications. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1016406
American Medical Association (AMA)
Barenghi, Rossella& Beke, Szabolcs& Romano, Ilaria& Gavazzo, Paola& Farkas, Balázs& Vassalli, Massimo…[et al.]. Elastin-Coated Biodegradable Photopolymer Scaffolds for Tissue Engineering Applications. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016406