Cadmium Increases the Sensitivity of Adolescent Female Mice to Nicotine-Related Behavioral Deficits
Joint Authors
Adeniyi, Philip Adeyemi
Olatunji, Babawale Peter
Ishola, Azeez Olakunle
Ajonijebu, Duyilemi Chris
Ogundele, Olalekan Michael
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study investigates spatial and nonspatial working memory, anxiety related behavior, and motor activities in cadmium and/or nicotine exposed female adolescent mice.
P28 female adolescent mice (albino strain) were divided into four groups of five (n=5) mice each.
A set of mice (Nic) received subcutaneous nicotine (2.0 mg/kg) while a separate set (Cd) was treated with 2.0 mg/kg cadmium (subcutaneous).
For the combined treatments of cadmium and nicotine, we administered 2.0 mg/kg Nicotine and 2.0 mg/kg of Cd.
Subsequently, a separate group of animals (n=5; control) received normal saline.
The total duration of treatment for all groups was 28 days (P28–P56).
At P56, the treatment was discontinued, after which the animals were examined in behavioural tests.
Nicotine and cadmium increased the metabolism and food intake in the female adolescent mice.
This also corresponded to an increase in weight when compared with the control.
However, a combined nicotine-cadmium treatment induced a decline in weight of the animals versus the control.
Also, nicotine administration increased the motor function, while cadmium and nicotine-cadmium treatment caused a decline in motor activity.
Both nicotine and cadmium induced a reduction in memory index; however, nicotine-cadmium treatment induced the most significant decrease in nonspatial working memory.
American Psychological Association (APA)
Adeniyi, Philip Adeyemi& Olatunji, Babawale Peter& Ishola, Azeez Olakunle& Ajonijebu, Duyilemi Chris& Ogundele, Olalekan Michael. 2014. Cadmium Increases the Sensitivity of Adolescent Female Mice to Nicotine-Related Behavioral Deficits. Behavioural Neurology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016677
Modern Language Association (MLA)
Adeniyi, Philip Adeyemi…[et al.]. Cadmium Increases the Sensitivity of Adolescent Female Mice to Nicotine-Related Behavioral Deficits. Behavioural Neurology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1016677
American Medical Association (AMA)
Adeniyi, Philip Adeyemi& Olatunji, Babawale Peter& Ishola, Azeez Olakunle& Ajonijebu, Duyilemi Chris& Ogundele, Olalekan Michael. Cadmium Increases the Sensitivity of Adolescent Female Mice to Nicotine-Related Behavioral Deficits. Behavioural Neurology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016677