Ethanolic Extract of Butea monosperma Leaves Elevate Blood Insulin Level in Type 2 Diabetic Rats, Stimulate Insulin Secretion in Isolated Rat Islets, and Enhance Hepatic Glycogen Formation
Joint Authors
Samad, Mehdi Bin
Kabir, Ashraf Ul
D'Costa, Ninadh Malrina
Akhter, Farjana
Ahmed, Arif
Jahan, Mohammad Rajib
Hannan, J. M. A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
We measured a vast range of parameters, in an attempt to further elucidate previously claimed antihyperglycemic activity of Butea monosperma.
Our study clearly negates the possibility of antidiabetic activity by inhibited gastrointestinal enzyme action or by reduced glucose absorption.
Reduction of fasting and postprandial glucose level was reconfirmed (P<0.05).
Improved serum lipid profile via reduced low density lipoprotein (LDL), cholesterol, triglycerides (TG), and increased high density lipoprotein (HDL) was also reestablished (P<0.05).
Significant insulin secretagogue activity of B.
monosperma was found in serum insulin assay of B.
monosperma treated type 2 diabetic rats (P<0.01).
This was further ascertained by our study on insulin secretion on isolated rat islets (P<0.05).
Improved sensitivity of glucose was shown by the significant increase in hepatic glycogen deposition (P<0.05).
Hence, we concluded that antihyperglycemic activity of B.
monosperma was mediated by enhanced insulin secretion and enhanced glycogen formation in the liver.
American Psychological Association (APA)
Samad, Mehdi Bin& Kabir, Ashraf Ul& D'Costa, Ninadh Malrina& Akhter, Farjana& Ahmed, Arif& Jahan, Mohammad Rajib…[et al.]. 2014. Ethanolic Extract of Butea monosperma Leaves Elevate Blood Insulin Level in Type 2 Diabetic Rats, Stimulate Insulin Secretion in Isolated Rat Islets, and Enhance Hepatic Glycogen Formation. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1018387
Modern Language Association (MLA)
Samad, Mehdi Bin…[et al.]. Ethanolic Extract of Butea monosperma Leaves Elevate Blood Insulin Level in Type 2 Diabetic Rats, Stimulate Insulin Secretion in Isolated Rat Islets, and Enhance Hepatic Glycogen Formation. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1018387
American Medical Association (AMA)
Samad, Mehdi Bin& Kabir, Ashraf Ul& D'Costa, Ninadh Malrina& Akhter, Farjana& Ahmed, Arif& Jahan, Mohammad Rajib…[et al.]. Ethanolic Extract of Butea monosperma Leaves Elevate Blood Insulin Level in Type 2 Diabetic Rats, Stimulate Insulin Secretion in Isolated Rat Islets, and Enhance Hepatic Glycogen Formation. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1018387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018387