Memory-Enhancing Effects of the Crude Extract of Polygala tenuifolia on Aged Mice
Joint Authors
Li, Zongyang
Liu, Yamin
Wang, Liwei
Liu, Xinmin
Chang, Qi
Guo, Zhi
Liao, Yonghong
Pan, Ruile
Fan, Tai-Ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Learning and memory disorders arise from distinct age-associated processes, and aging animals are often used as a model of memory impairment.
The root of Polygala tenuifolia has been commonly used in some Asian countries as memory enhancer and its memory improvement has been reported in various animal models.
However, there is less research to verify its effect on memory functions in aged animals.
Herein, the memory-enhancing effects of the crude extract of Polygala tenuifolia (EPT) on normal aged mice were assessed by Morris water maze (MWM) and step-down passive avoidance tests.
In MWM tests, the impaired spatial memory of the aged mice was partly reversed by EPT (100 and 200 mg/kg; P < 0.05) as compared with the aged control mice.
In step-down tests, the nonspatial memory of the aged mice was improved by EPT (100 and 200 mg/kg; P < 0.05).
Additionally, EPT could increase superoxide dismutase (SOD) and catalase (CAT) activities, inhibit monoamine oxidase (MAO) and acetyl cholinesterase (AChE) activities, and decrease the levels of malondialdehyde (MDA) in the brain tissue of the aged mice.
The results showed that EPT improved memory functions of the aged mice probably via its antioxidant properties and via decreasing the activities of MAO and AChE.
American Psychological Association (APA)
Li, Zongyang& Liu, Yamin& Wang, Liwei& Liu, Xinmin& Chang, Qi& Guo, Zhi…[et al.]. 2014. Memory-Enhancing Effects of the Crude Extract of Polygala tenuifolia on Aged Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018432
Modern Language Association (MLA)
Li, Zongyang…[et al.]. Memory-Enhancing Effects of the Crude Extract of Polygala tenuifolia on Aged Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018432
American Medical Association (AMA)
Li, Zongyang& Liu, Yamin& Wang, Liwei& Liu, Xinmin& Chang, Qi& Guo, Zhi…[et al.]. Memory-Enhancing Effects of the Crude Extract of Polygala tenuifolia on Aged Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018432