Preventive Effects of Collagen Peptide from Deer Sinew on Bone Loss in Ovariectomized Rats
Joint Authors
Zhang, He
Dong, Ying
Qi, Bin
Liu, Li
Zhou, Guangxin
Bai, Xueyuan
Yang, Chunhui
Zhao, Daqing
Zhao, Yu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Deer sinew (DS) has been used traditionally for various illnesses, and the major active constituent is collagen.
In this study, we assessed the effects of collagen peptide from DS on bone loss in the ovariectomized rats.
Wister female rats were randomly divided into six groups as follows: sham-operated (SHAM), ovariectomized control (OVX), OVX given 1.0 mg/kg/week nylestriol (OVX + N), OVX given 0.4 g/kg/day collagen peptide (OVX + H), OVX given 0.2 g/kg/day collagen peptide (OXV + M), and OVX given 0.1 g/kg/day collagen peptide (OXV + L), respectively.
After 13 weeks of treatment, the rats were euthanized, and the effects of collagen peptide on body weight, uterine weight, bone mineral density (BMD), serum biochemical indicators, bone histomorphometry, and bone mechanics were observed.
The data showed that BMD and concentration of serum hydroxyproline were significantly increased and the levels of serum calcium, phosphorus, and alkaline phosphatase were decreased.
Besides, histomorphometric parameters and mechanical indicators were improved.
However, collagen peptide of DS has no effect on estradiol level, body weight, and uterine weight.
Therefore, these results suggest that the collagen peptide supplementation may also prevent and treat bone loss.
American Psychological Association (APA)
Zhang, He& Dong, Ying& Qi, Bin& Liu, Li& Zhou, Guangxin& Bai, Xueyuan…[et al.]. 2014. Preventive Effects of Collagen Peptide from Deer Sinew on Bone Loss in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018759
Modern Language Association (MLA)
Zhang, He…[et al.]. Preventive Effects of Collagen Peptide from Deer Sinew on Bone Loss in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018759
American Medical Association (AMA)
Zhang, He& Dong, Ying& Qi, Bin& Liu, Li& Zhou, Guangxin& Bai, Xueyuan…[et al.]. Preventive Effects of Collagen Peptide from Deer Sinew on Bone Loss in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018759