Behavioral and Histopathological Study of Changes in Spinal Cord Injured Rats Supplemented with Spirulina platensis
Joint Authors
Aziz, Izzuddin
Che Ramli, Muhammad Danial
Mohd Zain, Nurul Suraya
Sanusi, Junedah
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Spinal cord injury (SCI) is a devastating disease that leads to permanent disability and causes great suffering.
The resulting neurological dysfunction and paralysis is proportional to the severity of the trauma itself.
Spirulina is widely used as a nutritional supplement due to its high protein and antioxidant content.
In the present study, the protective effect of the Spirulina treatment on locomotor function and morphological damage after SCI was investigated.
Seventy Sprague-Dawley (SD) rats were divided into three groups: Sham (laminectomy alone), Control (laminectomy with SCI), and Experimental (laminectomy with SCI +180 mg/kg per day Spirulina platensis).
A laminectomy was performed at T12 and an Inox No.2 modified forceps was used to perform a partial crush injury on the spinal cord.
The rats were then perfused at 3, 7, 14, 21, and 28 days after injury for morphological investigations.
The injured rat spinal cord indicated a presence of hemorrhage, cavity, and necrosis.
Pretreatment with Spirulina significantly improved the locomotor function and showed a significant reduction on the histological changes.
The experimental results observed in this study suggest that treatment with Spirulina platensis possesses potential benefits in improving hind limb locomotor function and reducing morphological damage to the spinal cord.
American Psychological Association (APA)
Aziz, Izzuddin& Che Ramli, Muhammad Danial& Mohd Zain, Nurul Suraya& Sanusi, Junedah. 2014. Behavioral and Histopathological Study of Changes in Spinal Cord Injured Rats Supplemented with Spirulina platensis. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1020359
Modern Language Association (MLA)
Aziz, Izzuddin…[et al.]. Behavioral and Histopathological Study of Changes in Spinal Cord Injured Rats Supplemented with Spirulina platensis. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1020359
American Medical Association (AMA)
Aziz, Izzuddin& Che Ramli, Muhammad Danial& Mohd Zain, Nurul Suraya& Sanusi, Junedah. Behavioral and Histopathological Study of Changes in Spinal Cord Injured Rats Supplemented with Spirulina platensis. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1020359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1020359