Synthesis of some new derivatives of pyrrolidine-2-one and studying their antibacterial potentials
Joint Authors
Kazim, Sahar A.
Betti, Nadiyah A.
Husayn, Rida Ib.
Source
Engineering and Technology Journal
Issue
Vol. 38, Issue 3B (31 Mar. 2020), pp.128-141, 14 p.
Publisher
Publication Date
2020-03-31
Country of Publication
Iraq
No. of Pages
14
Main Subjects
Topics
Abstract EN
New derivatives of pyrrolidine-2-one have been synthesized through lactamization of γ –butyrolactone (GBL) by hydrazine hydrate (80% ), ethylene diamine and ethanol amine to afford compounds (1-aminopyrrolidin-2-one), (1-(2-aminoethyl)pyrrolidine-2-one) and (1-(2-hydroxyethyl)pyrrolidine-2-one), respectively.
Compound (1-aminopyrrolidin-2-one) underwent several reactions to synthesize the rest of these derivatives.
All synthesized compounds were approved by their FT-IR, 1H-NMR and some by Mass spectra.
The biological activities of these derivatives were evaluated against Escherichia coli and Staphylococcus aureus.
Many of these derivatives showed moderate biological activity against one or both kind of bacteria in comparison to amoxicillin and some showed no biological activity at underwent several reactions to synthesize the rest of these derivatives.
All synthesized compounds were approved by their FT-IR, 1H-NMR and some by Mass spectra.
The biological activities of these derivatives were evaluated against Escherichia coli and Staphylococcus aureus.
Many of these derivatives showed moderate biological activity against one or both kind of bacteria in comparison to amoxicillin and some showed no biological activity at all
American Psychological Association (APA)
Betti, Nadiyah A.& Husayn, Rida Ib.& Kazim, Sahar A.. 2020. Synthesis of some new derivatives of pyrrolidine-2-one and studying their antibacterial potentials. Engineering and Technology Journal،Vol. 38, no. 3B, pp.128-141.
https://search.emarefa.net/detail/BIM-1020772
Modern Language Association (MLA)
Betti, Nadiyah A.…[et al.]. Synthesis of some new derivatives of pyrrolidine-2-one and studying their antibacterial potentials. Engineering and Technology Journal Vol. 38, no. 3B (2020), pp.128-141.
https://search.emarefa.net/detail/BIM-1020772
American Medical Association (AMA)
Betti, Nadiyah A.& Husayn, Rida Ib.& Kazim, Sahar A.. Synthesis of some new derivatives of pyrrolidine-2-one and studying their antibacterial potentials. Engineering and Technology Journal. 2020. Vol. 38, no. 3B, pp.128-141.
https://search.emarefa.net/detail/BIM-1020772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 140-141
Record ID
BIM-1020772
