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Enzyme activity and time-course quantitative distribution of an oral dose of imidacloprid in male rat tissues
Other Title(s)
النشاط الإنزيمي و المسار الزمني للتوزيع الكمي لجرعة فمية من الإيميداكلوبريد في أنسجة ذكور الجرذان
Joint Authors
Raghib, Didair Ahmad
Shalabi, Ata Mursi Ali
Nasr, Hibah Izzat
Sauve, Sebastien
Hindawi, Muhammad Yusuf
Source
Zagazig Journal for Agricultural Researches
Issue
Vol. 46, Issue 5 (31 Oct. 2019), pp.1387-1394, 8 p.
Publisher
Zagazig University Faculty of Agriculture
Publication Date
2019-10-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
The purpose of this study was to investigate the time course of changes in enzymes activity during distribution of imidaclopride (IMI) in Male Albino rat (Rattus norvegicus) after 1, 3, 6, 12, 24 and 48 hr.
, treatment with a single oral dose (20 mg/kg body weight).
The results showed significant gradual increase in liver and kidney function parameters coincided with accumulation of imidacloprid with varying quantities according to each organ, then gradually decreased to the end of study.
The highest activity in liver enzymes, ALT (97.33 U/L), AST (78 U/L) ALP (169.66 IU/L) and LDH (5190.67 U/L) was recorded six hours post treatment, as well as increasing in total protein (8.94 g/dl).
Kidney function parameters, i.
e.
urea, creatinine and uric acid levels (75.67, 2.283, 19.15 mg/dl, respectively) were also revealed the highest increase comparing with control.
Liver and brain acetylcholinesterase (AChE) activity was reached the lowest level with the inhibition percent 82.9, 81.4% , respectively at the same time agreed with the concentration peak of IMI in blood (8.04 µg/ml) liver (2.42 µg/g) and brain (4.06 µg/g).
The trend of maximal concentration of IMI in different organs and body fluids at six hours post dosing was in the following order: urine > blood > lungs > brain > testes > spleen > kidney > liver > muscles.
American Psychological Association (APA)
Nasr, Hibah Izzat& Shalabi, Ata Mursi Ali& Raghib, Didair Ahmad& Hindawi, Muhammad Yusuf& Sauve, Sebastien. 2019. Enzyme activity and time-course quantitative distribution of an oral dose of imidacloprid in male rat tissues. Zagazig Journal for Agricultural Researches،Vol. 46, no. 5, pp.1387-1394.
https://search.emarefa.net/detail/BIM-1021824
Modern Language Association (MLA)
Nasr, Hibah Izzat…[et al.]. Enzyme activity and time-course quantitative distribution of an oral dose of imidacloprid in male rat tissues. Zagazig Journal for Agricultural Researches Vol. 46, no. 5 (2019), pp.1387-1394.
https://search.emarefa.net/detail/BIM-1021824
American Medical Association (AMA)
Nasr, Hibah Izzat& Shalabi, Ata Mursi Ali& Raghib, Didair Ahmad& Hindawi, Muhammad Yusuf& Sauve, Sebastien. Enzyme activity and time-course quantitative distribution of an oral dose of imidacloprid in male rat tissues. Zagazig Journal for Agricultural Researches. 2019. Vol. 46, no. 5, pp.1387-1394.
https://search.emarefa.net/detail/BIM-1021824
Data Type
Journal Articles
Language
English
Notes
-
Record ID
BIM-1021824