Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis
Joint Authors
Tsuneyama, Koichi
Shimada, Tsutomu
Chen, Yen-Chen
Sasaki, Yoshiyuki
Suzuki, Wataru
Iizuka, Seiichi
Nagata, Mitsunobu
Aburada, Masaki
Chen, Shao-Yuan
Fujimoto, Makoto
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The effect of hyperbaric oxygen treatment (HBOT) was examined using MSG mice, which are an animal model of obesity, hyperlipidemia, diabetes, and nonalcoholic fatty liver disease.
Nineteen MSG male mice were divided into HBOT treated and control groups at 12 weeks of ages.
The HBOT group was treated with hyperbaric oxygen from 12 to 14 weeks (first phase) and then from 16 to 18 weeks (second phase).
Interestingly, the body weight of the HBOT group was significantly lower (P<0.01) than that of the control group.
In contrast, the serum lipid level did not show significant changes between the two groups.
As for the effects of increasing oxidative stress, the liver histology of the HBOT group showed severer cellular damage and aberrant TNF-α expression.
HBOT has the advantage of improving obesity in patients with metabolic syndrome, but the fault of causing organ damage by increasing oxidative stress.
American Psychological Association (APA)
Tsuneyama, Koichi& Chen, Yen-Chen& Fujimoto, Makoto& Sasaki, Yoshiyuki& Suzuki, Wataru& Shimada, Tsutomu…[et al.]. 2011. Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-1027873
Modern Language Association (MLA)
Tsuneyama, Koichi…[et al.]. Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis. The Scientific World Journal No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-1027873
American Medical Association (AMA)
Tsuneyama, Koichi& Chen, Yen-Chen& Fujimoto, Makoto& Sasaki, Yoshiyuki& Suzuki, Wataru& Shimada, Tsutomu…[et al.]. Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-1027873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027873