Analgesic and Anti-Inflammatory Activities of Methanol Extract of Ficus pumila L. in Mice
Joint Authors
Chang, Yuan-Shiun
Peng, Wen-Huang
Liao, Chi-Ren
Kao, Chun-Pin
Lai, Shang-Chih
Ho, Yu-Ling
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study investigated possible analgesic and anti-inflammatory mechanisms of the methanol extract of Ficus pumila (FPMeOH).
Analgesic effects were evaluated in two models including acetic acid-induced writhing response and formalin-induced paw licking.
The results showed FPMeOH decreased writhing response in the acetic acid assay and licking time in the formalin test.
The anti-inflammatory effect was evaluated by λ-carrageenan-induced mouse paw edema and histopathological analyses.
FPMeOH significantly decreased the volume of paw edema induced by λ-carrageenan.
Histopathologically, FPMeOH abated the level of tissue destruction and swelling of the edema paws.
This study indicated anti-inflammatory mechanism of FPMeOH may be due to declined levels of NO and MDA in the edema paw through increasing the activities of SOD, GPx, and GRd in the liver.
Additionally, FPMeOH also decreased the level of inflammatory mediators such as IL-1β, TNF-α, and COX-2.
HPLC fingerprint was established and the contents of three active ingredients, rutin, luteolin, and apigenin, were quantitatively determined.
This study provided evidence for the classical treatment of Ficus pumila in inflammatory diseases.
American Psychological Association (APA)
Liao, Chi-Ren& Kao, Chun-Pin& Peng, Wen-Huang& Chang, Yuan-Shiun& Lai, Shang-Chih& Ho, Yu-Ling. 2012. Analgesic and Anti-Inflammatory Activities of Methanol Extract of Ficus pumila L. in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028259
Modern Language Association (MLA)
Liao, Chi-Ren…[et al.]. Analgesic and Anti-Inflammatory Activities of Methanol Extract of Ficus pumila L. in Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028259
American Medical Association (AMA)
Liao, Chi-Ren& Kao, Chun-Pin& Peng, Wen-Huang& Chang, Yuan-Shiun& Lai, Shang-Chih& Ho, Yu-Ling. Analgesic and Anti-Inflammatory Activities of Methanol Extract of Ficus pumila L. in Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028259
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028259