Tocotrienol Supplementation Improves Late-Phase Fracture Healing Compared to Alpha-Tocopherol in a Rat Model of Postmenopausal Osteoporosis: A Biomechanical Evaluation
Joint Authors
Shuid, Ahmad Nazrun
Mohamad, Sharlina
Abdullah, Shahrum
Mokhtar, Sabarul Afian
Soelaiman, Ima Nirwana
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study investigated the effects of α-tocopherol and palm oil tocotrienol supplementations on bone fracture healing in postmenopausal osteoporosis rats.
32 female Sprague-Dawley rats were divided into four groups.
The first group was sham operated (SO), while the others were ovariectomised.
After 2 months, the right femora were fractured under anesthesia and fixed with K-wire.
The SO and ovariectomised-control rats (OVXC) were given olive oil (vehicle), while both the alpha-tocopherol (ATF) and tocotrienol-enriched fraction (TEF) groups were given alpha-tocopherol and tocotrienol-enriched fraction, respectively, at the dose of 60 mg/kg via oral gavages 6 days per week for 8 weeks.
The rats were then euthanized and the femora dissected out for bone biomechanical testing to assess their strength.
The callous of the TEF group had significantly higher stress parameter than the SO and OVXC groups.
Only the SO group showed significantly higher strain parameter compared to the other treatment groups.
The load parameter of the OVXC and ATF groups was significantly lower than the SO group.
There was no significant difference in the Young’s modulus between the groups.
In conclusion, tocotrienol is better than α-tocopherol in improving the biomechanical properties of the fracture callous in postmenopausal osteoporosis rat model.
American Psychological Association (APA)
Mohamad, Sharlina& Shuid, Ahmad Nazrun& Mokhtar, Sabarul Afian& Abdullah, Shahrum& Soelaiman, Ima Nirwana. 2012. Tocotrienol Supplementation Improves Late-Phase Fracture Healing Compared to Alpha-Tocopherol in a Rat Model of Postmenopausal Osteoporosis: A Biomechanical Evaluation. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028277
Modern Language Association (MLA)
Mohamad, Sharlina…[et al.]. Tocotrienol Supplementation Improves Late-Phase Fracture Healing Compared to Alpha-Tocopherol in a Rat Model of Postmenopausal Osteoporosis: A Biomechanical Evaluation. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028277
American Medical Association (AMA)
Mohamad, Sharlina& Shuid, Ahmad Nazrun& Mokhtar, Sabarul Afian& Abdullah, Shahrum& Soelaiman, Ima Nirwana. Tocotrienol Supplementation Improves Late-Phase Fracture Healing Compared to Alpha-Tocopherol in a Rat Model of Postmenopausal Osteoporosis: A Biomechanical Evaluation. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028277