Impact of Global Normalization in fMRI Acupuncture Studies
Joint Authors
Yang, Yang
Zhu, Yuanqiang
von Deneen, Karen M.
Jin, Lingmin
Dong, Minghao
Yang, Xuejuan
Gong, Qiyong
Tian, Jie
Sun, Jinbo
Qin, Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-17
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Global normalization is often used as a preprocessing step for dispelling the “nuisance effects.” However, it has been shown in cognitive and emotion tasks that this preprocessing step might greatly distort statistical results when the orthogonality assumption of global normalization is violated.
The present study examines this issue in fMRI acupuncture studies.
Thirty healthy subjects were recruited to evaluate the impacts of the global normalization on the BOLD responses evoked by acupuncture stimulation during De-qi sensation and tactile stimulation during nonpainful sensations.
To this end, we compared results by conducting global normalization (PSGS) and not conducting global normalization (NO PSGS) based on a proportional scaling model.
The orthogonality assumption of global normalization was violated, and significant changes between BOLD responses for NO PSGS and PSGS were shown in most subjects.
Extensive deactivations of acupuncture in fMRI were the non-specifically pernicious consequences of global normalization.
The central responses of acupuncture during De-qi are non-specifically activation-dominant at the somatosensory-related brain network, whose statistical power is specifically enhanced by PSGS.
In conclusion, PSGS should be unjustified for acupuncture studies in fMRI.
The differences including the global normalization or not may partly contribute to conflicting results and interpretations in previous fMRI acupuncture studies.
American Psychological Association (APA)
Sun, Jinbo& Qin, Wei& Jin, Lingmin& Dong, Minghao& Yang, Xuejuan& Zhu, Yuanqiang…[et al.]. 2012. Impact of Global Normalization in fMRI Acupuncture Studies. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-22.
https://search.emarefa.net/detail/BIM-1028327
Modern Language Association (MLA)
Sun, Jinbo…[et al.]. Impact of Global Normalization in fMRI Acupuncture Studies. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-22.
https://search.emarefa.net/detail/BIM-1028327
American Medical Association (AMA)
Sun, Jinbo& Qin, Wei& Jin, Lingmin& Dong, Minghao& Yang, Xuejuan& Zhu, Yuanqiang…[et al.]. Impact of Global Normalization in fMRI Acupuncture Studies. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-22.
https://search.emarefa.net/detail/BIM-1028327
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028327