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Effects of Eurycoma longifolia on Testosterone Level and Bone Structure in an Aged Orchidectomised Rat Model
Joint Authors
Shuid, Ahmad Nazrun
Ima-Nirwana, Soelaiman
Tajul Ariff, Abdul Shukor
Pramanik, J.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Testosterone replacement is the choice of treatment in androgen-deficient osteoporosis.
However, long-term use of testosterone is potentially carcinogenic.
Eurycoma longifolia (EL) has been reported to enhance testosterone level and prevent bone calcium loss but there is a paucity of research regarding its effect on the bone structural parameters.
This study was conducted to explore the bone structural changes following EL treatment in normal and androgen-deficient osteoporosis rat model.
Thirty-six male Sprague-Dawley rats aged 12 months were divided into normal control, normal rat supplemented with EL, sham-operated, orchidectomised-control, orchidectomised with testosterone replacement, and orchidectomised with EL supplementation groups.
Testosterone serum was measured both before and after the completion of the treatment.
After 6 weeks of the treatment, the femora were processed for bone histomorphometry.
Testosterone replacement was able to raise the testosterone level and restore the bone volume of orchidectomised rats.
EL supplementation failed to emulate both these testosterone actions.
The inability of EL to do so may be related to the absence of testes in the androgen deficient osteoporosis model for EL to stimulate testosterone production.
American Psychological Association (APA)
Tajul Ariff, Abdul Shukor& Ima-Nirwana, Soelaiman& Pramanik, J.& Shuid, Ahmad Nazrun. 2012. Effects of Eurycoma longifolia on Testosterone Level and Bone Structure in an Aged Orchidectomised Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028558
Modern Language Association (MLA)
Tajul Ariff, Abdul Shukor…[et al.]. Effects of Eurycoma longifolia on Testosterone Level and Bone Structure in an Aged Orchidectomised Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028558
American Medical Association (AMA)
Tajul Ariff, Abdul Shukor& Ima-Nirwana, Soelaiman& Pramanik, J.& Shuid, Ahmad Nazrun. Effects of Eurycoma longifolia on Testosterone Level and Bone Structure in an Aged Orchidectomised Rat Model. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028558
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028558