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Ginsenoside-Rg1 Protects the Liver against Exhaustive Exercise-Induced Oxidative Stress in Rats
Joint Authors
Korivi, Mallikarjuna
Hou, Chien-Wen
Lee, Shin-Da
Hsu, Ming-Fen
Yu, Szu-Hsien
Chen, Chung-Yu
Liu, Yung-Yang
Huang, Chih-Yang
Kuo, Chia-Hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Despite regular exercise benefits, acute exhaustive exercise elicits oxidative damage in liver.
The present study determined the hepatoprotective properties of ginsenoside-Rg1 against exhaustive exercise-induced oxidative stress in rats.
Forty rats were assigned into vehicle and ginsenoside-Rg1 groups (0.1 mg/kg bodyweight).
After 10-week treatment, ten rats from each group performed exhaustive swimming.
Estimated oxidative damage markers, including thiobarbituric acid reactive substance (TBARS) (67%) and protein carbonyls (56%), were significantly (P<0.01) elevated after exhaustive exercise but alleviated in ginsenoside-Rg1 pretreated rats.
Furthermore, exhaustive exercise drastically decreased glutathione (GSH) content (~79%) with concurrent decreased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities.
However, these changes were attenuated in Rg1 group.
Additionally, increased xanthine oxidase (XO) activity and nitric oxide (NO) levels after exercise were also inhibited by Rg1 pretreatment.
For the first time, our findings provide strong evidence that ginsenoside-Rg1 can protect the liver against exhaustive exercise-induced oxidative damage.
American Psychological Association (APA)
Korivi, Mallikarjuna& Hou, Chien-Wen& Huang, Chih-Yang& Lee, Shin-Da& Hsu, Ming-Fen& Yu, Szu-Hsien…[et al.]. 2011. Ginsenoside-Rg1 Protects the Liver against Exhaustive Exercise-Induced Oxidative Stress in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028629
Modern Language Association (MLA)
Korivi, Mallikarjuna…[et al.]. Ginsenoside-Rg1 Protects the Liver against Exhaustive Exercise-Induced Oxidative Stress in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028629
American Medical Association (AMA)
Korivi, Mallikarjuna& Hou, Chien-Wen& Huang, Chih-Yang& Lee, Shin-Da& Hsu, Ming-Fen& Yu, Szu-Hsien…[et al.]. Ginsenoside-Rg1 Protects the Liver against Exhaustive Exercise-Induced Oxidative Stress in Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028629
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028629