Assessment of Hereditary Retinal Degeneration in the English Springer Spaniel Dog and Disease Relationship to an RPGRIP1 Mutation
Joint Authors
Narfström, Kristina
Jeong, Manbok
Hyman, Jennifer
Madsen, Richard W.
Bergström, Tomas F.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Intensive breeding and selection on desired traits have produced high rates of inherited diseases in dogs.
Hereditary retinal degeneration, often called progressive retinal atrophy (PRA), is prevalent in dogs with disease entities comparable to human retinitis pigmentosa (RP) and Leber’s congenital amaurosis (LCA).
Recent molecular studies in the English Springer Spaniel (ESS) dog have shown that PRA cases are often homozygous for a mutation in the RPGRIP1 gene, the defect also causing human RP, LCA, and cone rod dystrophies.
The present study characterizes the disease in a group of affected ESS in USA, using clinical, functional, and morphological studies.
An objective evaluation of retinal function using electroretinography (ERG) is further performed in a masked fashion in a group of American ESS dogs, with the examiner masked to the genetic status of the dogs.
Only 4 of 6 homozygous animals showed clinical signs of disease, emphasizing the need and importance for more precise studies on the clinical expression of molecular defects before utilizing animal models for translational research, such as when using stem cells for therapeutic intervention.
American Psychological Association (APA)
Narfström, Kristina& Jeong, Manbok& Hyman, Jennifer& Madsen, Richard W.& Bergström, Tomas F.. 2012. Assessment of Hereditary Retinal Degeneration in the English Springer Spaniel Dog and Disease Relationship to an RPGRIP1 Mutation. Stem Cells International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1030037
Modern Language Association (MLA)
Narfström, Kristina…[et al.]. Assessment of Hereditary Retinal Degeneration in the English Springer Spaniel Dog and Disease Relationship to an RPGRIP1 Mutation. Stem Cells International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1030037
American Medical Association (AMA)
Narfström, Kristina& Jeong, Manbok& Hyman, Jennifer& Madsen, Richard W.& Bergström, Tomas F.. Assessment of Hereditary Retinal Degeneration in the English Springer Spaniel Dog and Disease Relationship to an RPGRIP1 Mutation. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1030037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030037