Improved Early Postresuscitation EEG Activity for Animals Treated with Hypothermia Predicted 96 hr Neurological Outcome and Survival in a Rat Model of Cardiac Arrest
Joint Authors
Li, Yongqin
Song, Feng-Qing
Sun, Lei-Lei
Lei, Ling-Yan
Gan, Wei-Ni
Chen, Meng-Hua
Chen, Bihua
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To investigate the effect of hypothermia on 96 hr neurological outcome and survival by quantitatively characterizing early postresuscitation EEG in a rat model of cardiac arrest.
Materials and Methods.
In twenty male Sprague-Dawley rats, cardiac arrest was induced through high frequency transesophageal cardiac pacing.
Cardiopulmonary resuscitation was initiated after 5 mins untreated arrest.
Immediately after resuscitation, animals were randomized to either 2 hrs of hypothermia (N=10) or normothermia (N=10).
EEG, ECG, aortic pressure, and core temperature were continuously recorded for 6 hrs.
Neurological outcome was evaluated daily during the 96 hrs postresuscitation period.
Results.
No differences in the baseline measurements and resuscitation outcome were observed between groups.
However, 96 hr neurological deficit score (204 ± 255 versus 500 ± 0, P=0.005) and survival (6/10 versus 0/10, P=0.011) were significantly better in the hypothermic group.
Quantitative analysis of early postresuscitation EEG revealed that burst frequency and spectrum entropy were greatly improved in the hypothermic group and correlated with 96 hr neurological outcome and survival.
Conclusion.
The improved burst frequency during burst suppression period and preserved spectrum entropy after restoration of continuous background EEG activity for animals treated with hypothermia predicted favorable neurological outcome and survival in this rat model of cardiac arrest.
American Psychological Association (APA)
Chen, Bihua& Song, Feng-Qing& Sun, Lei-Lei& Lei, Ling-Yan& Gan, Wei-Ni& Chen, Meng-Hua…[et al.]. 2013. Improved Early Postresuscitation EEG Activity for Animals Treated with Hypothermia Predicted 96 hr Neurological Outcome and Survival in a Rat Model of Cardiac Arrest. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030355
Modern Language Association (MLA)
Chen, Bihua…[et al.]. Improved Early Postresuscitation EEG Activity for Animals Treated with Hypothermia Predicted 96 hr Neurological Outcome and Survival in a Rat Model of Cardiac Arrest. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030355
American Medical Association (AMA)
Chen, Bihua& Song, Feng-Qing& Sun, Lei-Lei& Lei, Ling-Yan& Gan, Wei-Ni& Chen, Meng-Hua…[et al.]. Improved Early Postresuscitation EEG Activity for Animals Treated with Hypothermia Predicted 96 hr Neurological Outcome and Survival in a Rat Model of Cardiac Arrest. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030355