Effect of sweet and bitter lupin on blood sugar of hyperglycemic rats

Abstract EN

Nowadays, tend to use synthetic drugs to lower serum glucose in diabetic patients is gradually decreased because of their related side effects.

In this regard, tend to use of medicinal plants has been doubled.

Therefore, this work was conducted to investigate the effect of lupin seeds at the level of (5, 10, and 15) % on diabetic rats.

Forty male albino mice were used and were split to two main groups (n=5 rat).

In the headmost group rats fed on the basal diet only as a control negative group.

The followed group injected with alloxan and split into seven groups.

Group (1) was eaten diet containing un-fortified bread.

Group (2), (3) and (4) were fed on diet containing bread fortified with 5%, 10% and 15% bitter lupin, respectively.

Group (5), (6) and (7) were fed on diet containing fortified bread with 5%, 10% and 15% sweet lupin, respectively.

At the end of the experimental time (6 weeks), rats were killed and blood samples were taken to obtain serum.

Results indicated that supplementation with bread of (5, 10 and 15) % sweet and bitter lupin in the diet caused considerably (P<0.05) lower in sugar level compared to the positive group.

It was also observed that liver functions of the treated rats were improved compared to the positive control group.

In conclusion, sweet and bitter lupin could be used as an appropriate supplementation treatment for diabetic patients.