Diffusion-Weighted Magnetic Resonance Application in Response Prediction before, during, and after Neoadjuvant Radiochemotherapy in Primary Rectal Cancer Carcinoma

Joint Authors

Magnante, Anna Lisa
Ciolina, Maria
De Cecco, Carlo Nicola
Rengo, Marco
Raffetto, Nicola
Redler, Adriano
Tombolini, Vincenzo
De Felice, Francesca
Musio, Daniela
Laghi, Andrea

Source

BioMed Research International

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-07-10

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Medicine

Abstract EN

Introduction.

Our interest was to monitor treatment response using ADC value to predict response of rectal tumour to preoperative radiochemotherapy.

Materials and Methods.

Twenty-two patients were treated with long course of radiochemotherapy, followed by surgery.

Patients were examined by diffusion-weighted imaging MRI at three-time points (prior, during, and after radiochemotherapy) and were classified as responders and nonresponders.

Results.

A statistical significant correlation was found between preradiochemotherapy ADC values and during treatment ADC values, in responders (F=21.50, P value <0.05).

An increase in ADC value during treatment was predictive of at least a partial response.

Discussion.

Response of tumour to neoadjuvant therapy cannot be easily evaluated, and such capability might be of great importance in clinical practice, because the number of irradiated and operated patients may be superior to the number of who will really benefit from this multimodal treatment.

A reliable prediction of the final clinical TN stage would allow radiotherapist to adapt multidisciplinary approach to a less invasive management, sparing surgical procedure in responder patients or even allowing an early surgery in nonresponders, which would significantly reduce radiochemotherapy related toxicity.

Conclusion.

Early evaluation of response during neoadjuvant radiochemotherapy treatment shows great promise to predict tumour response.

American Psychological Association (APA)

Musio, Daniela& De Felice, Francesca& Magnante, Anna Lisa& Ciolina, Maria& De Cecco, Carlo Nicola& Rengo, Marco…[et al.]. 2013. Diffusion-Weighted Magnetic Resonance Application in Response Prediction before, during, and after Neoadjuvant Radiochemotherapy in Primary Rectal Cancer Carcinoma. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030862

Modern Language Association (MLA)

Musio, Daniela…[et al.]. Diffusion-Weighted Magnetic Resonance Application in Response Prediction before, during, and after Neoadjuvant Radiochemotherapy in Primary Rectal Cancer Carcinoma. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1030862

American Medical Association (AMA)

Musio, Daniela& De Felice, Francesca& Magnante, Anna Lisa& Ciolina, Maria& De Cecco, Carlo Nicola& Rengo, Marco…[et al.]. Diffusion-Weighted Magnetic Resonance Application in Response Prediction before, during, and after Neoadjuvant Radiochemotherapy in Primary Rectal Cancer Carcinoma. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030862

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1030862