Predicting the DPP-IV Inhibitory Activity pIC50 Based on Their Physicochemical Properties
Joint Authors
Gu, Tianhong
Yang, Xiaoyan
Zhang, Yuhui
Wu, Milin
Li, M. J.
Lu, W. C.
Lv, Y. L.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The second development program developed in this work was introduced to obtain physicochemical properties of DPP-IV inhibitors.
Based on the computation of molecular descriptors, a two-stage feature selection method called mRMR-BFS (minimum redundancy maximum relevance-backward feature selection) was adopted.
Then, the support vector regression (SVR) was used in the establishment of the model to map DPP-IV inhibitors to their corresponding inhibitory activity possible.
The squared correlation coefficient for the training set of LOOCV and the test set are 0.815 and 0.884, respectively.
An online server for predicting inhibitory activity pIC50 of the DPP-IV inhibitors as described in this paper has been given in the introduction.
American Psychological Association (APA)
Gu, Tianhong& Li, M. J.& Wu, Milin& Lv, Y. L.& Lu, W. C.& Zhang, Yuhui…[et al.]. 2013. Predicting the DPP-IV Inhibitory Activity pIC50 Based on Their Physicochemical Properties. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030932
Modern Language Association (MLA)
Gu, Tianhong…[et al.]. Predicting the DPP-IV Inhibitory Activity pIC50 Based on Their Physicochemical Properties. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030932
American Medical Association (AMA)
Gu, Tianhong& Li, M. J.& Wu, Milin& Lv, Y. L.& Lu, W. C.& Zhang, Yuhui…[et al.]. Predicting the DPP-IV Inhibitory Activity pIC50 Based on Their Physicochemical Properties. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030932