Lactobacilli Reduce Chemokine IL-8 Production in Response to TNF-α and Salmonella Challenge of Caco-2 Cells
Joint Authors
Qin, Yan-Qing
Yin, Rong-Lan
Ye, Fei
Liu, Hong-Feng
Wang, Mao-Peng
Sun, Yang
Li, Xiao
Tian, Ming-Yao
Jin, Ning-Yi
Li, Chang
Du, Shouwen
Ren, Dayong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The probiotic properties of two selected lactobacilli strains were assessed.
L.
salivarius and L.
plantarum displayed higher hydrophobicity (48% and 54%, resp.) and coaggregation ability with four pathogens (from 7.9% to 57.5%).
L.
salivarius and L.
plantarum had good inhibitory effects on S.
aureus (38.2% and 49.5%, resp.) attachment to Caco-2 cells.
Live lactobacilli strains and their conditioned media effectively inhibited IL-8 production (<14.6 pg/mL) in TNF-α-induced Caco-2 cells.
Antibiotic-treated and the sonicated lactobacilli also maintained inhibitory effects (IL-8 production from 5.0 to 36.3 pg/mL); however, the heat-treated lactobacilli lost their inhibitory effects (IL-8 production from 130.2 to 161.0 pg/mL).
These results suggest that both the structural components and the soluble cellular content of lactobacilli have anti-inflammatory effects.
We also found that pretreatment of Caco-2 cells with lactobacilli inhibited S.
typhimurium-induced IL-8 production (<27.3 pg/mL).
However, lactobacilli did not inhibit IL-8 production in Caco-2 cells pretreated with S.
typhimurium.
These results suggest that the tested lactobacilli strains are appropriate for preventing inflammatory diseases caused by enteric pathogens but not for therapy.
In short, L.
salivarius and L.
plantarum are potential candidates for the development of microbial ecological agents and functional foods.
American Psychological Association (APA)
Ren, Dayong& Li, Chang& Qin, Yan-Qing& Yin, Rong-Lan& Du, Shouwen& Ye, Fei…[et al.]. 2013. Lactobacilli Reduce Chemokine IL-8 Production in Response to TNF-α and Salmonella Challenge of Caco-2 Cells. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031100
Modern Language Association (MLA)
Ren, Dayong…[et al.]. Lactobacilli Reduce Chemokine IL-8 Production in Response to TNF-α and Salmonella Challenge of Caco-2 Cells. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1031100
American Medical Association (AMA)
Ren, Dayong& Li, Chang& Qin, Yan-Qing& Yin, Rong-Lan& Du, Shouwen& Ye, Fei…[et al.]. Lactobacilli Reduce Chemokine IL-8 Production in Response to TNF-α and Salmonella Challenge of Caco-2 Cells. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031100
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031100