![](/images/graphics-bg.png)
Pulmonary Innate Immune Response and Melatonin Receptors in the Perinatal Stress
Joint Authors
Corrêa, Rosana Rosa Miranda
Vinícius da Silva, Marcos
Rocha, Laura Penna
Guimarães, Camila Souza de Oliveira
Olegário, Janaínna Grazielle Pacheco
Reis, Marlene Antônia dos
Machado, Juliana Reis
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
To analyze the cytokines of the innate immune pulmonary response and the capacity for local response to melatonin according to the perinatal stress.
Methods.
49 cases of pediatric autopsies were evaluated, divided according to cause of death, perinatal stress, gestational age, and birth weight.
The percentages of IL-6, C-reactive protein (CRP), IL-1β, TNF-α, and melatonin receptor were evaluated by immunohistochemistry.
Results.
The IL-6 expression was higher in the children showing chronic stress, anoxia, and infection.
The IL-6 expression showed a progressive increase according to the relation between weight and GA.
There was no significant difference in the expression of IL-1β and TNF-α.
The CRP expression was higher in the cases showing chronic stress and premature cases.
The expression of melatonin receptors was significantly higher in the cases showing chronic stress, being more evident in the cases showing infection.
Conclusion.
The cause of death and the type of stress influence the expression in situ of melatonin and cytokines of the innate immune pulmonary response.
The evaluation of IL-6 and CRP may contribute to the understanding of the evolution of neonates with chronic stress.
The greater sensitivity of the lung to melatonin in these cases may indicate an attempt at controlling the immunological response, in an attempt to diminish the harmful effects of stress.
American Psychological Association (APA)
Olegário, Janaínna Grazielle Pacheco& Vinícius da Silva, Marcos& Machado, Juliana Reis& Rocha, Laura Penna& Reis, Marlene Antônia dos& Guimarães, Camila Souza de Oliveira…[et al.]. 2013. Pulmonary Innate Immune Response and Melatonin Receptors in the Perinatal Stress. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1031275
Modern Language Association (MLA)
Olegário, Janaínna Grazielle Pacheco…[et al.]. Pulmonary Innate Immune Response and Melatonin Receptors in the Perinatal Stress. Journal of Immunology Research No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1031275
American Medical Association (AMA)
Olegário, Janaínna Grazielle Pacheco& Vinícius da Silva, Marcos& Machado, Juliana Reis& Rocha, Laura Penna& Reis, Marlene Antônia dos& Guimarães, Camila Souza de Oliveira…[et al.]. Pulmonary Innate Immune Response and Melatonin Receptors in the Perinatal Stress. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1031275
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031275