![](/images/graphics-bg.png)
Effects of Chitosan Alkali Pretreatment on the Preparation of Electrospun PCLChitosan Blend Nanofibrous Scaffolds for Tissue Engineering Application
Joint Authors
Sultana, Naznin
Roozbahani, Fatemeh
Fauzi Ismail, Ahmad
Nouparvar, Hamed
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Recently, nanofibrous scaffolds have been used in the field of biomedical engineering as wound dressings, tissue engineering scaffolds, and drug delivery applications.
The electrospun nanofibrous scaffolds can be used as carriers for several types of drugs, genes, and growth factors.
PCL is one of the most commonly applied synthetic polymers for medical use because of its biocompatibility and slow biodegradability.
PCL is hydrophobic and has no cell recognition sites on its structure.
Electrospinning of chitosan and PCL blend was investigated in formic acid/acetic acid as the solvent with different PCL/chitosan ratios.
High viscosity of chitosan solutions makes difficulties in the electrospinning process.
Strong hydrogen bonds in a 3D network in acidic condition prevent the movement of polymeric chains exposed to the electrical field.
Consequently, the amount of chitosan in PCL/chitosan blend was limited and more challenging when the concentration of PCL increases.
The treatment of chitosan in alkali condition under high temperature reduced its molecular weight.
Longer treatment time further decreased the molecular weight of chitosan and hence its viscosity.
Electrospinning of PCL/chitosan blend was possible at higher chitosan ratio, and SEM images showed a decrease in fiber diameter and narrower distribution with increase in the chitosan ratio.
American Psychological Association (APA)
Roozbahani, Fatemeh& Sultana, Naznin& Fauzi Ismail, Ahmad& Nouparvar, Hamed. 2013. Effects of Chitosan Alkali Pretreatment on the Preparation of Electrospun PCLChitosan Blend Nanofibrous Scaffolds for Tissue Engineering Application. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031497
Modern Language Association (MLA)
Roozbahani, Fatemeh…[et al.]. Effects of Chitosan Alkali Pretreatment on the Preparation of Electrospun PCLChitosan Blend Nanofibrous Scaffolds for Tissue Engineering Application. Journal of Nanomaterials No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031497
American Medical Association (AMA)
Roozbahani, Fatemeh& Sultana, Naznin& Fauzi Ismail, Ahmad& Nouparvar, Hamed. Effects of Chitosan Alkali Pretreatment on the Preparation of Electrospun PCLChitosan Blend Nanofibrous Scaffolds for Tissue Engineering Application. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031497