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Reducing Agents Decrease the Oxidative Burst and Improve Clinical Outcomes in COPD Patients: A Randomised Controlled Trial on the Effects of Sulphurous Thermal Water Inhalation
Joint Authors
Contoli, Marco
Gnesini, Giulia
Forini, Giacomo
Marku, Brunilda
Pauletti, Alessia
Padovani, Anna
Casolari, Paolo
Taurino, Liliana
Ferraro, Andrea
Chicca, Milva
Ciaccia, Adalberto
Pinamonti, Silvano
Papi, Alberto
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Inhalation of thermal water with antioxidant properties is empirically used for COPD.
Aims.
To evaluate the effects of sulphurous thermal water (reducing agents) on airway oxidant stress and clinical outcomes in COPD.
Methods.
Forty moderate-to-severe COPD patients were randomly assigned to receive 12-day inhalation with sulphurous thermal water or isotonic saline.
Patients were assessed for superoxide anion (O2-) production in the exhaled breath condensate and clinical outcomes at recruitment, the day after the conclusion of the 12-day inhalation treatment, and one month after the end of the inhalation treatment.
Results.
Inhalation of reducing agents resulted in a significant reduction of O2- production in exhaled breath condensate of COPD patients at the end of the inhalatory treatment and at followup compared to baseline.
A significant improvement in the COPD assessment test (CAT) questionnaire was shown one month after the end of the inhalatory treatment only in patients receiving sulphurous water.
Conclusion.
Thermal water inhalation produced an in vivo antioxidant effect and improvement in health status in COPD patients.
Larger studies are required in order to evaluate whether inhalation of thermal water is able to modify relevant clinical outcomes of the disease (the study was registered at clinicaltrial.gov—identifier: NCT01664767).
American Psychological Association (APA)
Contoli, Marco& Gnesini, Giulia& Forini, Giacomo& Marku, Brunilda& Pauletti, Alessia& Padovani, Anna…[et al.]. 2013. Reducing Agents Decrease the Oxidative Burst and Improve Clinical Outcomes in COPD Patients: A Randomised Controlled Trial on the Effects of Sulphurous Thermal Water Inhalation. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1033444
Modern Language Association (MLA)
Contoli, Marco…[et al.]. Reducing Agents Decrease the Oxidative Burst and Improve Clinical Outcomes in COPD Patients: A Randomised Controlled Trial on the Effects of Sulphurous Thermal Water Inhalation. The Scientific World Journal No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1033444
American Medical Association (AMA)
Contoli, Marco& Gnesini, Giulia& Forini, Giacomo& Marku, Brunilda& Pauletti, Alessia& Padovani, Anna…[et al.]. Reducing Agents Decrease the Oxidative Burst and Improve Clinical Outcomes in COPD Patients: A Randomised Controlled Trial on the Effects of Sulphurous Thermal Water Inhalation. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1033444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1033444