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Emerging Anticancer Potentials of Goniothalamin and Its Molecular Mechanisms
Joint Authors
Jantan, Ibrahim
Seyed, Mohamed Ali
Bukhari, Syed Nasir Abbas
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The treatment of most cancers is still inadequate, despite tremendous steady progress in drug discovery and effective prevention.
Nature is an attractive source of new therapeutics.
Several medicinal plants and their biomarkers have been widely used for the treatment of cancer with less known scientific basis of their functioning.
Although a wide array of plant derived active metabolites play a role in the prevention and treatment of cancer, more extensive scientific evaluation of their mechanisms is still required.
Styryl-lactones are a group of secondary metabolites ubiquitous in the genus Goniothalamus that have demonstrated to possess antiproliferative activity against cancer cells.
A large body of evidence suggests that this activity is associated with the induction of apoptosis in target cells.
In an effort to promote further research on the genus Goniothalamus, this review offers a broad analysis of the current knowledge on Goniothalamin (GTN) or 5, 6, dihydro-6-styryl-2-pyronone (C13H12O2), a natural occurring styryl-lactone.
Therefore, it includes (i) the source of GTN and other metabolites; (ii) isolation, purification, and (iii) the molecular mechanisms of actions of GTN, especially the anticancer properties, and summarizes the role of GTN which is crucial for drug design, development, and application in future for well-being of humans.
American Psychological Association (APA)
Seyed, Mohamed Ali& Jantan, Ibrahim& Bukhari, Syed Nasir Abbas. 2014. Emerging Anticancer Potentials of Goniothalamin and Its Molecular Mechanisms. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034493
Modern Language Association (MLA)
Seyed, Mohamed Ali…[et al.]. Emerging Anticancer Potentials of Goniothalamin and Its Molecular Mechanisms. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1034493
American Medical Association (AMA)
Seyed, Mohamed Ali& Jantan, Ibrahim& Bukhari, Syed Nasir Abbas. Emerging Anticancer Potentials of Goniothalamin and Its Molecular Mechanisms. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034493