Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment
Joint Authors
Pawar, Chandrakala R.
Jagdale, Swati C.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Migraine follows circadian rhythm in which headache is more painful at the awakening time.
This needs administration of dosage form at night time to release drug after lag period when pain gets worse.
Sumatriptan succinate is a drug of choice for migraine.
Sumatriptan succinate has bitter taste, low oral bioavailability, and shorter half-life.
Present work deals with application of design of experiment for polyox and xanthan gum in development of press coated floating pulsatile tablet.
Floating pulsatile concept was applied to increase gastric residence of the dosage form.
Burst release was achieved through immediate release tablet using crospovidone as superdisintegrant (10%).
Pulse lag time was achieved using swellable polymer polyox WSR 205 and xanthan gum.
32 experimental design was applied.
Optimized formulation was evaluated for physical characteristics and in-vitro and in-vivo study.
From results, it can be concluded that optimized batch F8 containing polyox WSR205 (72.72%) and xanthan gum (27.27%) of total weight of polymer has shown floating lag time of 55 ± 2 sec, drug content of 100.35 ± 0.4%, hardness of 6 ± 0.1 Kg/cm2, and 98.69 ± 2% drug release in pulse manner with lag time of 7 ± 0.1 h.
Optimized batch showed prolong gastric residence which was confirmed by in-vivo X-ray study.
American Psychological Association (APA)
Jagdale, Swati C.& Pawar, Chandrakala R.. 2014. Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034496
Modern Language Association (MLA)
Jagdale, Swati C.& Pawar, Chandrakala R.. Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1034496
American Medical Association (AMA)
Jagdale, Swati C.& Pawar, Chandrakala R.. Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034496