Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment

Joint Authors

Pawar, Chandrakala R.
Jagdale, Swati C.

Source

BioMed Research International

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-10-28

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Migraine follows circadian rhythm in which headache is more painful at the awakening time.

This needs administration of dosage form at night time to release drug after lag period when pain gets worse.

Sumatriptan succinate is a drug of choice for migraine.

Sumatriptan succinate has bitter taste, low oral bioavailability, and shorter half-life.

Present work deals with application of design of experiment for polyox and xanthan gum in development of press coated floating pulsatile tablet.

Floating pulsatile concept was applied to increase gastric residence of the dosage form.

Burst release was achieved through immediate release tablet using crospovidone as superdisintegrant (10%).

Pulse lag time was achieved using swellable polymer polyox WSR 205 and xanthan gum.

32 experimental design was applied.

Optimized formulation was evaluated for physical characteristics and in-vitro and in-vivo study.

From results, it can be concluded that optimized batch F8 containing polyox WSR205 (72.72%) and xanthan gum (27.27%) of total weight of polymer has shown floating lag time of 55 ± 2 sec, drug content of 100.35 ± 0.4%, hardness of 6 ± 0.1 Kg/cm2, and 98.69 ± 2% drug release in pulse manner with lag time of 7 ± 0.1 h.

Optimized batch showed prolong gastric residence which was confirmed by in-vivo X-ray study.

American Psychological Association (APA)

Jagdale, Swati C.& Pawar, Chandrakala R.. 2014. Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034496

Modern Language Association (MLA)

Jagdale, Swati C.& Pawar, Chandrakala R.. Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1034496

American Medical Association (AMA)

Jagdale, Swati C.& Pawar, Chandrakala R.. Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034496

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1034496