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Serum Prolidase Activity and Oxidative Stress in Diabetic Nephropathy and End Stage Renal Disease: A Correlative Study with Glucose and Creatinine
Joint Authors
Verma, Akhilesh Kumar
Chandra, Subhash
Singh, Rana Gopal
Singh, Tej Bali
Srivastava, Ragini
Srivastava, Shalabh
Source
Biochemistry Research International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Association of oxidative stress and serum prolidase activity (SPA) has been reported in many chronic diseases.
The study was aimed at evaluating the correlation of glucose and creatinine to SPA and oxidative stress in patients with diabetic nephropathy (DN) and end stage renal disease (ESRD) concerned with T2DM.
50 healthy volunteers, 50 patients with T2DM, 86 patients with DN, and 43 patients with ESRD were considered as control-1, control-2, case-1, and case-2, respectively.
Blood glucose, creatinine, SPA, total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) were measured by colorimetric tests.
SPA, TOS, and OSI were significantly increased in case-1 and case-2 than control-1 and control-2, while TAS was significantly decreased (P<0.001).
Blood glucose was linearly correlated to SPA, TOS, TAS, and OSI in control-2, case-1 and case-2 (P<0.001).
Serum creatinine was linearly correlated with SPA, TOS, TAS and OSI in control-2 and case-1 (P<0.001).
In case-2, serum creatinine was significantly correlated with SPA only (P<0.001).
Thus, the study concluded that SPA and oxidative stress significantly correlated with blood glucose and creatinine.
SPA, TOS, TAS, and OSI can be used as biomarkers for diagnosis of kidney damage.
American Psychological Association (APA)
Verma, Akhilesh Kumar& Chandra, Subhash& Singh, Rana Gopal& Singh, Tej Bali& Srivastava, Shalabh& Srivastava, Ragini. 2014. Serum Prolidase Activity and Oxidative Stress in Diabetic Nephropathy and End Stage Renal Disease: A Correlative Study with Glucose and Creatinine. Biochemistry Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034626
Modern Language Association (MLA)
Verma, Akhilesh Kumar…[et al.]. Serum Prolidase Activity and Oxidative Stress in Diabetic Nephropathy and End Stage Renal Disease: A Correlative Study with Glucose and Creatinine. Biochemistry Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1034626
American Medical Association (AMA)
Verma, Akhilesh Kumar& Chandra, Subhash& Singh, Rana Gopal& Singh, Tej Bali& Srivastava, Shalabh& Srivastava, Ragini. Serum Prolidase Activity and Oxidative Stress in Diabetic Nephropathy and End Stage Renal Disease: A Correlative Study with Glucose and Creatinine. Biochemistry Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034626
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034626