Anti-NMDA Receptor Encephalitis Presenting as an Acute Psychotic Episode in a Young Woman: An Underdiagnosed yet Treatable Disorder
Joint Authors
Keller, Shikma
Roitman, Pablo
Bonne, Omer
Lotan, Amit
Ben-Hur, T.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-07
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Anti-NMDA receptor (NMDAR) encephalitis is a recently identified autoimmune disorder with prominent psychiatric symptoms.
Patients usually present with acute behavioral change, psychosis, catatonic symptoms, memory deficits, seizures, dyskinesias, and autonomic instability.
In female patients an ovarian teratoma is often identified.
We describe a 32-year-old woman who presented with acute psychosis.
Shortly after admission, she developed generalized seizures and deteriorated into a catatonic state.
Although ancillary tests including MRI, electroencephalogram, and cerebrospinal fluid (CSF) analysis were unremarkable, the presentation of acute psychosis in combination with recurrent seizures and a relentless course suggested autoimmune encephalitis.
The patient underwent pelvic ultrasound which disclosed a dermoid cyst and which led to an urgent cystectomy.
Plasmapheresis was then initiated, yielding partial response over the next two weeks.
Following the detection of high titers of anti-NMDAR antibodies in the CSF, the patient ultimately received second line immunosuppressive treatment with rituximab.
Over several months of cognitive rehabilitation a profound improvement was eventually noted, although minor anterograde memory deficits remained.
In this report we call for attention to the inclusion of anti-NMDAR encephalitis in the differential diagnosis of acute psychosis.
Prompt diagnosis is critical as early immunotherapy and tumor removal could dramatically affect outcomes.
American Psychological Association (APA)
Keller, Shikma& Roitman, Pablo& Ben-Hur, T.& Bonne, Omer& Lotan, Amit. 2014. Anti-NMDA Receptor Encephalitis Presenting as an Acute Psychotic Episode in a Young Woman: An Underdiagnosed yet Treatable Disorder. Case Reports in Psychiatry،Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-1034934
Modern Language Association (MLA)
Keller, Shikma…[et al.]. Anti-NMDA Receptor Encephalitis Presenting as an Acute Psychotic Episode in a Young Woman: An Underdiagnosed yet Treatable Disorder. Case Reports in Psychiatry No. 2014 (2014), pp.1-3.
https://search.emarefa.net/detail/BIM-1034934
American Medical Association (AMA)
Keller, Shikma& Roitman, Pablo& Ben-Hur, T.& Bonne, Omer& Lotan, Amit. Anti-NMDA Receptor Encephalitis Presenting as an Acute Psychotic Episode in a Young Woman: An Underdiagnosed yet Treatable Disorder. Case Reports in Psychiatry. 2014. Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-1034934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034934