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Efficacy and Safety of Clearing Heat and Detoxifying Injection in the Treatment of Influenza: A Randomized, Double-Blinded, Placebo-Controlled Trial
Joint Authors
Wei, Baolin
Liu, Xinqiao
Zhang, Yaqing
Huang, Xiaomin
Tan, Yuping
Sun, Zengtao
Yu, Liu
Yuhong, Huang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To evaluate the efficacy and safety of CHDI in the treatment of influenza infection.
Method.
A randomized double-blind, double dummy trial was conducted.
Influenza patients with a positive influenza A rapid test diagnosis were randomized to receive CHDI or oseltamivir.
Primary outcome was assessed by the median fever alleviation time and clearance time, and secondary outcome was total scores of influenza symptoms.
Results.
One hundred thirty-nine participants were screened and 34 had a RT-PCR laboratory confirmation of influenza virus infection.
Fever alleviation time was 2.5 and 5 hours in CHDI and oseltamivir, respectively, and fever clearance time was 32.5 and 49 hours.
The HR of fever alleviation and clearance time shows no significant difference between two groups.
Total scores of influenza symptoms descended significantly in both groups after treatment and descended more in CHDI than oseltamivir on day 2.
Similar to total symptoms severity score, fever severity score descend more significantly in CHDI than oseltamivir on day 2, and there were no differences on other symptoms.
Conclusions.
CHDI have a similar effect to oseltamivir in reducing the duration of influenza illness.
CHDI was well tolerated, with no serious adverse events noted during the study period.
American Psychological Association (APA)
Yu, Liu& Yuhong, Huang& Wei, Baolin& Liu, Xinqiao& Zhang, Yaqing& Huang, Xiaomin…[et al.]. 2014. Efficacy and Safety of Clearing Heat and Detoxifying Injection in the Treatment of Influenza: A Randomized, Double-Blinded, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035107
Modern Language Association (MLA)
Yu, Liu…[et al.]. Efficacy and Safety of Clearing Heat and Detoxifying Injection in the Treatment of Influenza: A Randomized, Double-Blinded, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035107
American Medical Association (AMA)
Yu, Liu& Yuhong, Huang& Wei, Baolin& Liu, Xinqiao& Zhang, Yaqing& Huang, Xiaomin…[et al.]. Efficacy and Safety of Clearing Heat and Detoxifying Injection in the Treatment of Influenza: A Randomized, Double-Blinded, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035107