Comparison of the Effects of Acarbose and TZQ-F, a New Kind of Traditional Chinese Medicine to Treat Diabetes, Chinese Healthy Volunteers
Joint Authors
Baohe, Wang
Wenxu, Fu
Yanfen, Li
Ziqiang, Li
Liu, Yang
Shirong, Liu
Jinxia, Sun
Na, Li
Deqin, Zhang
Yu, Liu
Yuhong, Huang
Gao, Xiumei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ethnopharmacological Relevance.
TZQ-F has been traditionally used in Traditional Chinese Medicine as a formula for the treatment of diabetes.
Aim of the Study.
This study aims to compare the pharmacologic effects and gastrointestinal adverse events between TZQ-F and acarbose.
Methods.
The double-blind randomized placebo-controlled fivefold crossover study was performed in 20 healthy male volunteers.
Plasma glucose, plasma IRI, and plasma C-peptide were measured to assess the pharmacologic effects.
Flatus and bowel activity were measured to assess the adverse event of gastrointestinal effect.
Results.
3 and 4 tablets of TZQ decreased the Cmax of plasma glucose compared with that of the previous day and with placebo.
3 tablets also decreased Cmax of plasma C-peptide compared with placebo.
4 tablets increased Cmax of plasma insulin after breakfast and the AUC of plasma C-peptide after breakfast and dinner.
2 tablets did not decrease plasma glucose and elevated the Cmax and AUC of C-peptide after breakfast and dinner, respectively.
Acarbose 50 mg decreased the Cmax of plasma insulin and C-peptide after breakfast and the Cmax of plasma glucose and C-peptide after dinner.
The subjects who received TZQ did not report any abdominal adverse events.
Conclusions.
3 tablets of TZQ have the same effects as the acarbose.
American Psychological Association (APA)
Yuhong, Huang& Wenxu, Fu& Yanfen, Li& Yu, Liu& Ziqiang, Li& Liu, Yang…[et al.]. 2014. Comparison of the Effects of Acarbose and TZQ-F, a New Kind of Traditional Chinese Medicine to Treat Diabetes, Chinese Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035150
Modern Language Association (MLA)
Yuhong, Huang…[et al.]. Comparison of the Effects of Acarbose and TZQ-F, a New Kind of Traditional Chinese Medicine to Treat Diabetes, Chinese Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035150
American Medical Association (AMA)
Yuhong, Huang& Wenxu, Fu& Yanfen, Li& Yu, Liu& Ziqiang, Li& Liu, Yang…[et al.]. Comparison of the Effects of Acarbose and TZQ-F, a New Kind of Traditional Chinese Medicine to Treat Diabetes, Chinese Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035150
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035150