A Network Pharmacology Approach to Determine Active Compounds and Action Mechanisms of Ge-Gen-Qin-Lian Decoction for Treatment of Type 2 Diabetes
Joint Authors
Zhang, Bo
Li, Hui-Ying
Zhao, Linhua
Jiang, Yuyu
Guo, Yun
Liu, Hongxing
Tong, Xiaolin
Li, Shao
Wang, Xu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Traditional Chinese medicine (TCM) herbal formulae can be valuable therapeutic strategies and drug discovery resources.
However, the active ingredients and action mechanisms of most TCM formulae remain unclear.
Therefore, the identification of potent ingredients and their actions is a major challenge in TCM research.
In this study, we used a network pharmacology approach we previously developed to help determine the potential antidiabetic ingredients from the traditional Ge-Gen-Qin-Lian decoction (GGQLD) formula.
We predicted the target profiles of all available GGQLD ingredients to infer the active ingredients by clustering the target profile of ingredients with FDA-approved antidiabetic drugs.
We also applied network target analysis to evaluate the links between herbal ingredients and pharmacological actions to help explain the action mechanisms of GGQLD.
According to the predicted results, we confirmed that a novel antidiabetic ingredient from Puerariae Lobatae radix (Ge-Gen), 4-Hydroxymephenytoin, increased the insulin secretion in RIN-5F cells and improved insulin resistance in 3T3-L1 adipocytes.
The network pharmacology strategy used here provided a powerful means for identifying bioactive ingredients and mechanisms of action for TCM herbal formulae, including Ge-Gen-Qin-Lian decoction.
American Psychological Association (APA)
Li, Hui-Ying& Zhao, Linhua& Zhang, Bo& Jiang, Yuyu& Wang, Xu& Guo, Yun…[et al.]. 2014. A Network Pharmacology Approach to Determine Active Compounds and Action Mechanisms of Ge-Gen-Qin-Lian Decoction for Treatment of Type 2 Diabetes. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1035231
Modern Language Association (MLA)
Li, Hui-Ying…[et al.]. A Network Pharmacology Approach to Determine Active Compounds and Action Mechanisms of Ge-Gen-Qin-Lian Decoction for Treatment of Type 2 Diabetes. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1035231
American Medical Association (AMA)
Li, Hui-Ying& Zhao, Linhua& Zhang, Bo& Jiang, Yuyu& Wang, Xu& Guo, Yun…[et al.]. A Network Pharmacology Approach to Determine Active Compounds and Action Mechanisms of Ge-Gen-Qin-Lian Decoction for Treatment of Type 2 Diabetes. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1035231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035231