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Amides from Piper as a Diuretic: Behind the Ethnopharmacological Uses of Piper glabratum Kunth
Joint Authors
Botelho Lourenço, Emerson Luiz
Lima Prando, Thiago Bruno
Gasparotto Junior, Arquimedes
Baciquete, Tatiane da Fonseca
Vieira, Jennifer Alexandra Castanho
Bressan, Jaqueline
Gasparotto, Francielly Mourão
Jesus, Douglas Rossi
Cardozo Junior, Euclides Lara
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Several species of the genus Piper are known in Brazilian folk medicine as having diuretic activity.
So, we propose to investigate the acute diuretic activity and the possible toxic effects of Piper glabratum Kunth, popularly known as false Jaborandi.
Additionally, we propose to check whether there is any correlation between the biological activities of the crude extract (MEPG) and its 2-methoxy-4,5-methylenedioxy-trans-cinnamoyl-pyrrolidine (MMCP) in Wistar rats.
The MEPG was fractioned by chromatography column and the MMCP was identified by analyses of 1H and 13C RMN spectral data and correlations.
Both MEPG and MMCP were assayed for diuretic activity.
The preparations obtained were orally administered in a single dose to rats.
The urine excretion, pH, density, conductivity, and content of Na+, K+, Cl−, and HCO 3 - were measured in the urine of saline-loaded animals.
Additionally, acute toxicity of the extract was also evaluated.
MMCP at doses of 30 mg/kg was able to increase the urine volume, pH, and HCO 3 - excretion.
Moreover, high dosage of MEPG showed important liver toxicity and elevated mortality when injected intraperitoneally.
The results indicate that the MMCP shows important diuretic properties when administered in Wistar rats.
Additionally, MEPG can induce important acute toxicity if given in high doses.
American Psychological Association (APA)
Lima Prando, Thiago Bruno& Baciquete, Tatiane da Fonseca& Vieira, Jennifer Alexandra Castanho& Bressan, Jaqueline& Gasparotto, Francielly Mourão& Jesus, Douglas Rossi…[et al.]. 2014. Amides from Piper as a Diuretic: Behind the Ethnopharmacological Uses of Piper glabratum Kunth. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1035303
Modern Language Association (MLA)
Lima Prando, Thiago Bruno…[et al.]. Amides from Piper as a Diuretic: Behind the Ethnopharmacological Uses of Piper glabratum Kunth. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1035303
American Medical Association (AMA)
Lima Prando, Thiago Bruno& Baciquete, Tatiane da Fonseca& Vieira, Jennifer Alexandra Castanho& Bressan, Jaqueline& Gasparotto, Francielly Mourão& Jesus, Douglas Rossi…[et al.]. Amides from Piper as a Diuretic: Behind the Ethnopharmacological Uses of Piper glabratum Kunth. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1035303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035303