Effect of Integrated Cognitive Therapy on Hippocampal Functional Connectivity Patterns in Stroke Patients with Cognitive Dysfunction: A Resting-State fMRI Study
Joint Authors
Yang, Shanli
Jiang, Cai
Ye, Haicheng
Tao, Jing
Huang, Jia
Gao, Yanling
Lin, Zhicheng
Chen, Lidian
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
This study aimed to identify abnormal hippocampal functional connectivity (FC) following ischemic stroke using resting-state fMRI.
We also explored whether abnormal hippocampal FC could be modulated by integrated cognitive therapy and tested whether these alterations were associated with cognitive performance.
Methods.
18 right-handed cognitively impaired ischemic stroke patients and 18 healty control (HC) subjects were included in this study.
Stroke subjects were scanned at baseline and after integrated cognitive therapy, while HCs were only scanned at baseline, to identify regions that show significant correlations with the seed region.
Behavioral and cognitive assessments were obtained before each scan.
Results.
During the resting state, we found abnormal hippocampal FC associated with temporal regions, insular cortex, cerebellum, and prefrontal cortex in stroke patients compared to HCs.
After integrated cognitive therapy, however, the stroke group showed increased hippocampal FC mainly located in the prefrontal gyrus and the default mode network (DMN).
Altered hippocampal FC was associated with cognitive improvement.
Conclusion.
Resting-state fMRI may provide novel insight into the study of functional networks in the brain after stroke.
Furthermore, altered hippocampal FC may be a compensatory mechanism for cognitive recovery after ischemic stroke.
American Psychological Association (APA)
Yang, Shanli& Jiang, Cai& Ye, Haicheng& Tao, Jing& Huang, Jia& Gao, Yanling…[et al.]. 2014. Effect of Integrated Cognitive Therapy on Hippocampal Functional Connectivity Patterns in Stroke Patients with Cognitive Dysfunction: A Resting-State fMRI Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035495
Modern Language Association (MLA)
Yang, Shanli…[et al.]. Effect of Integrated Cognitive Therapy on Hippocampal Functional Connectivity Patterns in Stroke Patients with Cognitive Dysfunction: A Resting-State fMRI Study. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035495
American Medical Association (AMA)
Yang, Shanli& Jiang, Cai& Ye, Haicheng& Tao, Jing& Huang, Jia& Gao, Yanling…[et al.]. Effect of Integrated Cognitive Therapy on Hippocampal Functional Connectivity Patterns in Stroke Patients with Cognitive Dysfunction: A Resting-State fMRI Study. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035495
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035495