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An Emerging Translational Model to Screen Potential Medicinal Plants for Nephrolithiasis, an Independent Risk Factor for Chronic Kidney Disease
Joint Authors
Chen, Huey-Yi
Chen, Wen-Chi
Man, Kee-Ming
Lin, Wei-Yun
Wu, San-Yuan
Tsai, Kao-Sung
Lee, Yuan-Ju
Shen, Jui-Lung
Tsai, Fuu-Jen
Chen, Yung-Hsiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Pharmacological therapy for urolithiasis using medicinal plants has been increasingly adopted for the prevention of its recurrence.
A Drosophila melanogaster model developed for translational research of urolithiasis was applied to evaluate agents with potential antilithic effects and calcium oxalate (CaOx) formation.
Potential antilithic herbs were prepared in a mixture of food in a diluted concentration of 5,000 from the original extract with 0.5% ethylene glycol (EG) as the lithogenic agent.
The control group was fed with food only.
After 3 weeks, flies ( n ≥ 150 for each group) were killed using CO2 narcotization, and the Malpighian tubules were dissected, removed, and processed for polarized light microscopy examination of the crystals.
The crystal formation rate in the EG group was 100.0%.
In the study, 16 tested herbal drugs reached the crystal formation rate of 0.0%, including Salviae miltiorrhizae, Paeonia lactiflora, and Carthami flos.
Scutellaria baicalensis enhanced CaOx crystal formation.
Two herbal drugs Commiphora molmol and Natrii sulfas caused the death of all flies.
Our rapid screening methods provided evidence that some medicinal plants have potential antilithic effects.
These useful medicinal plants can be further studied using other animal or human models to verify their effects.
American Psychological Association (APA)
Wu, San-Yuan& Shen, Jui-Lung& Man, Kee-Ming& Lee, Yuan-Ju& Chen, Huey-Yi& Chen, Yung-Hsiang…[et al.]. 2014. An Emerging Translational Model to Screen Potential Medicinal Plants for Nephrolithiasis, an Independent Risk Factor for Chronic Kidney Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035510
Modern Language Association (MLA)
Wu, San-Yuan…[et al.]. An Emerging Translational Model to Screen Potential Medicinal Plants for Nephrolithiasis, an Independent Risk Factor for Chronic Kidney Disease. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035510
American Medical Association (AMA)
Wu, San-Yuan& Shen, Jui-Lung& Man, Kee-Ming& Lee, Yuan-Ju& Chen, Huey-Yi& Chen, Yung-Hsiang…[et al.]. An Emerging Translational Model to Screen Potential Medicinal Plants for Nephrolithiasis, an Independent Risk Factor for Chronic Kidney Disease. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035510