Assessment of Gastric Phenotypes Using Magnifying Narrow-Band Imaging for Differentiation of Gastric Carcinomas from Adenomas
Joint Authors
Kobayashi, Masaaki
Hashimoto, Satoru
Nishikura, Ken
Mizuno, Ken-Ichi
Takeuchi, Manabu
Ajioka, Yoichi
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Conventional white-light endoscopy and forceps biopsy are insufficient for definitive diagnosis of gastric adenoma.
Immunohistochemical studies have reported an obvious phenotypic difference between adenomas and carcinomas.
We investigated the utility of narrow-band imaging with magnifying endoscopy (NBI-ME) for mucin phenotypic assessment to differentiate carcinomas from adenomas.
Methods.
NBI-ME findings were classified into A, B, and AB types, which revealed papillary, tubular pits and groove microstructures, respectively.
To investigate A-B classifications retrospectively, 137 patients (155 lesions) that were diagnosed pretherapeutically with adenoma or borderline lesions by biopsy were enrolled.
The mucin phenotype was analyzed immunohistochemically in the first 60 lesions.
Results.
After endoscopic submucosal dissection, A type and AB type lesions were determined histologically as carcinoma (81/82, 99%).
B type lesions were adenoma (29/73, 40%) and carcinoma (44/73, 60%).
A or AB type correlated to histological carcinomas (sensitivity 65%, specificity 97%, and accuracy 71%).
Mucin phenotypes were gastric or gastrointestinal in A type and AB type carcinomas (31/37, 84%) and intestinal in B type adenomas and carcinomas (21/23, 91%).
Conclusions.
NBI-ME has the advantage of the assessment of mucin phenotypes in gastric carcinomas and adenomas.
The proposed A-B classification is useful, especially for differentiation of gastric or gastrointestinal carcinomas from adenomas.
American Psychological Association (APA)
Kobayashi, Masaaki& Hashimoto, Satoru& Nishikura, Ken& Mizuno, Ken-Ichi& Takeuchi, Manabu& Ajioka, Yoichi. 2014. Assessment of Gastric Phenotypes Using Magnifying Narrow-Band Imaging for Differentiation of Gastric Carcinomas from Adenomas. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035879
Modern Language Association (MLA)
Kobayashi, Masaaki…[et al.]. Assessment of Gastric Phenotypes Using Magnifying Narrow-Band Imaging for Differentiation of Gastric Carcinomas from Adenomas. Gastroenterology Research and Practice No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035879
American Medical Association (AMA)
Kobayashi, Masaaki& Hashimoto, Satoru& Nishikura, Ken& Mizuno, Ken-Ichi& Takeuchi, Manabu& Ajioka, Yoichi. Assessment of Gastric Phenotypes Using Magnifying Narrow-Band Imaging for Differentiation of Gastric Carcinomas from Adenomas. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035879