Breast Cancer with Neoductgenesis: Histopathological Criteria and Its Correlation with Mammographic and Tumour Features
Joint Authors
Fjallskog, Marie-Louise
Pinder, Sarah E.
Sollie, Thomas
Christensson, Gunilla
Abdsaleh, Shahin
Tot, Tibor
Wärnberg, Fredrik
Blomqvist, Carl
Amini, Rose-Marie
Zhou, Wenjing
Source
International Journal of Breast Cancer
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
Breast cancer with mammographic casting type calcifications, high grade DCIS with an abnormal number of ducts, periductal desmoplastic reaction, lymphocyte infiltration, and tenascin-C (TN-C) overexpression has been proposed to represent a more aggressive form of breast cancer and has been denominated as breast cancer with neoductgenesis.
We developed histopathological criteria for neoductgenesis in order to study reproducibility and correlation with other tumour markers.
Methods.
74 cases of grades 2 and 3 DCIS, with or without an invasive component, were selected.
A combined score of the degree(s) of concentration of ducts, lymphocyte infiltration, and periductal fibrosis was used to classify cases as showing neoductgenesis, or not.
Diagnostic reproducibility, correlation with tumour markers, and mammographic features were studied.
Results.
Twenty-three of 74 cases were diagnosed with neoductgenesis.
The kappa value between pathologists showed moderate reproducibility (0.50) (95% CI; 0.41–0.60).
Neoductgenesis correlated significantly with malignant type microcalcifications and TN-C expression ( P = 0.008 and 0.04) and with ER, PR, and HER2 status ( P < 0.00001 for all three markers).
Conclusions.
We developed histological criteria for breast cancer with neoductgenesis.
Neoductgenesis, by our applied histopathological definition was related to more aggressive tumour biology and malignant mammographic calcifications.
American Psychological Association (APA)
Zhou, Wenjing& Sollie, Thomas& Tot, Tibor& Pinder, Sarah E.& Amini, Rose-Marie& Blomqvist, Carl…[et al.]. 2014. Breast Cancer with Neoductgenesis: Histopathological Criteria and Its Correlation with Mammographic and Tumour Features. International Journal of Breast Cancer،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036306
Modern Language Association (MLA)
Zhou, Wenjing…[et al.]. Breast Cancer with Neoductgenesis: Histopathological Criteria and Its Correlation with Mammographic and Tumour Features. International Journal of Breast Cancer No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1036306
American Medical Association (AMA)
Zhou, Wenjing& Sollie, Thomas& Tot, Tibor& Pinder, Sarah E.& Amini, Rose-Marie& Blomqvist, Carl…[et al.]. Breast Cancer with Neoductgenesis: Histopathological Criteria and Its Correlation with Mammographic and Tumour Features. International Journal of Breast Cancer. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036306