Increased Incidence of Thyroid Dysfunction and Autoimmunity in Patients with Vernal Keratoconjunctivitis
Joint Authors
Stagi, Stefano
de Martino, Maurizio
Pucci, Neri
Di Grande, Laura
de Libero, Cinzia
Caputo, Roberto
Pantano, Stefano
Mattei, Ivan
Mori, Francesca
Novembre, Elio
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Hormones may play a role in the pathophysiology of vernal keratoconjunctivitis (VKC).
An increased incidence of thyroid autoantibodies was recently observed in VKC, although there were no data on thyroid function.
Two hundred and eighty-eight patients (202 males, 86 females; range 5.5 to 16.9 years) with VKC were evaluated and compared with 188 normal age- and sex-matched subjects.
In all subjects, serum concentrations of free T4, TSH, thyroperoxidase, thyroglobulin, and TSHr autoantibodies were evaluated.
In VKC, the family history of thyroid diseases showed no significant differences compared to the controls (9.4 versus 8.6%), whereas the family history of autoimmune diseases was significantly higher (13.2% versus 6.3%; P < 0.05 ).
Subclinical hypothyroidism was diagnosed in 6.6% (versus 1.6% of the controls; P < 0.05 ) and overt hypothyroidism in 0.7% (versus 0.0% of the controls; P = N S ).
Finally, 5.2% of patients were positive for thyroid autoantibodies, which were significantly higher with respect to the controls (0.5%, P < 0.05 ).
In the patients positive for thyroid autoantibodies, 80% showed a sonography pattern that suggested autoimmune thyroiditis.
Thyroid function and autoimmunity abnormalities are frequently present in children with VKC.
Children with VKC should be screened for thyroid function and evaluated for thyroid autoimmunity.
American Psychological Association (APA)
Stagi, Stefano& Pucci, Neri& Di Grande, Laura& de Libero, Cinzia& Caputo, Roberto& Pantano, Stefano…[et al.]. 2014. Increased Incidence of Thyroid Dysfunction and Autoimmunity in Patients with Vernal Keratoconjunctivitis. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036593
Modern Language Association (MLA)
Stagi, Stefano…[et al.]. Increased Incidence of Thyroid Dysfunction and Autoimmunity in Patients with Vernal Keratoconjunctivitis. International Journal of Endocrinology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036593
American Medical Association (AMA)
Stagi, Stefano& Pucci, Neri& Di Grande, Laura& de Libero, Cinzia& Caputo, Roberto& Pantano, Stefano…[et al.]. Increased Incidence of Thyroid Dysfunction and Autoimmunity in Patients with Vernal Keratoconjunctivitis. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036593