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Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy
Joint Authors
Mamone, Leandro
Sáenz, Daniel
Vallecorsa, Pablo
Batlle, Alcira
Casas, Adriana
Di Venosa, Gabriela
Source
International Journal of Photoenergy
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue.
The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage.
It is believed that singlet oxygen is responsible for that skin photosensitization.
The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs.
C.
argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line.
The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells.
C.
argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment.
We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity.
American Psychological Association (APA)
Mamone, Leandro& Sáenz, Daniel& Vallecorsa, Pablo& Batlle, Alcira& Casas, Adriana& Di Venosa, Gabriela. 2014. Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy. International Journal of Photoenergy،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036927
Modern Language Association (MLA)
Mamone, Leandro…[et al.]. Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy. International Journal of Photoenergy No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036927
American Medical Association (AMA)
Mamone, Leandro& Sáenz, Daniel& Vallecorsa, Pablo& Batlle, Alcira& Casas, Adriana& Di Venosa, Gabriela. Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy. International Journal of Photoenergy. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036927