تحضير و تشخيص بعض من قواعد شيف المشتقة من الكاربوكسي مثيل كايتوسان و تقييم الفعالية البايولوجية لبعض منها

Abstract EN

This study included the synthesis of O-carboxymethyl chitosan which contains amine group attached directly to its glucose unit from the well-known natural polymer (chitosan), which in turn was reacted with some aromatic aldehydes containing o- and p- substituents to prepare a series of Schiff bases compounds.

The used aldehydes were; p-boromobenzaldehyde, o-hydroxybenzaldehyde, o-bromobenzaldehyde, p-chlorobenzaldehyde, and p-nitrobenzaldehyde.

The synthesized compounds were characterized using spectroscopic techniques including FT-IR and 1H-NMR.

The thermal stability of some of the prepared compounds was checked using differential thermaogravimetric analysis DTA.

Finally, the biological activity of two Schiff bases was measured against two types of bacteria (Escherichia coli) and (Staphylococcus aureus) in terms of inhibition rate.