Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide
Joint Authors
Voukali, Maria
Kastrinelli, Irene
Stragalinou, Sapfo
Tasiopoulou, Dimitra
Paraskevopoulou, Pinelopi
Katsilambros, Nicholas
Ioannidis, Ioannis
Tentolouris, Nicholas
Kokkinos, Alexander
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Therapeutic approaches based on the actions of the incretin hormone GLP-1 have been widely established in the management of T2DM.
Nevertheless, much less research has been aimed at elucidating the role of GLP-1 in lipid metabolism and in particular postprandial dyslipidemia.
Exenatide and liraglutide are two GLP-1 receptor agonists which are currently available as subcutaneously administered treatment for T2DM but their chronic effects on postprandial lipaemia have not been well investigated.
The aim of this study is to examine the effect of treatment with either liraglutide or exenatide for two weeks on postprandial lipaemia in obese subjects with T2DM.
This study was a single-center, two-armed, randomized, controlled 2-week prospective intervention trial in 20 subjects with T2DM.
Patients were randomized to receive either liraglutide or exenatide treatment and underwent a standardized meal tolerance test early in the morning after 10 h fast at baseline (visit 1, beginning of treatment) and after a two-week treatment period (visit 2).
Exenatide and liraglutide both appear to be equally effective in lowering postprandial lipaemia after the first administration and after a two-week treatment.
The mechanisms which lead to this phenomenon, which seem to be independent of gastric emptying, are yet to be studied.
American Psychological Association (APA)
Voukali, Maria& Kastrinelli, Irene& Stragalinou, Sapfo& Tasiopoulou, Dimitra& Paraskevopoulou, Pinelopi& Katsilambros, Nicholas…[et al.]. 2014. Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040284
Modern Language Association (MLA)
Voukali, Maria…[et al.]. Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide. Journal of Diabetes Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040284
American Medical Association (AMA)
Voukali, Maria& Kastrinelli, Irene& Stragalinou, Sapfo& Tasiopoulou, Dimitra& Paraskevopoulou, Pinelopi& Katsilambros, Nicholas…[et al.]. Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040284