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Acarbose Treatment and the Risk of Cardiovascular Disease in Type 2 Diabetic Patients: A Nationwide Seven-Year Follow-Up Study
Joint Authors
Chen, Jui-Ming
Chang, Cheng-Wei
Lin, Ying-Chieh
Sheu, Wayne Huey-Herng
Horng, Jorng-Tzong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To investigate the potential benefits of acarbose treatment on cardiovascular disease (CVD) in patients with type 2 diabetes by using nationwide insurance claim dataset.
Research Design and Methods.
Among 644,792 newly diagnosed type 2 diabetic patients without preexisting CVD in a nationwide cohort study, 109,139 (16.9%) who had received acarbose treatment were analyzed for CVD risk.
Those with CVD followed by acarbose therapy were also subjected to analysis.
Result.
During 7 years of follow-up, 5,081 patients (4.7%) developed CVD.
The crude hazard ratio (HR) and adjusted HR were 0.66 and 0.99, respectively.
The adjusted HR of CVD was 1.19, 0.70, and 0.38 when the duration of acarbose use was <12 months, 12–24 months, and >24 months, respectively.
Adjusted HR was 1.14, 0.64, and 0.41 with acarbose cumulative doses <54,750 mg, 54,751 to 109,500 mg, and >109,500 mg, respectively.
Conclusion.
In patients with type 2 diabetes without preexisting CVD, treatment with acarbose showed a transient increase in incidence of CVD in the initial 12 months followed by significant reductions of CVD in prolonged acarbose users.
After the first CVD events, continuous use of acarbose revealed neutral effect within the first 12 months.
The underlying mechanisms require further investigations.
American Psychological Association (APA)
Chen, Jui-Ming& Chang, Cheng-Wei& Lin, Ying-Chieh& Horng, Jorng-Tzong& Sheu, Wayne Huey-Herng. 2014. Acarbose Treatment and the Risk of Cardiovascular Disease in Type 2 Diabetic Patients: A Nationwide Seven-Year Follow-Up Study. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040379
Modern Language Association (MLA)
Chen, Jui-Ming…[et al.]. Acarbose Treatment and the Risk of Cardiovascular Disease in Type 2 Diabetic Patients: A Nationwide Seven-Year Follow-Up Study. Journal of Diabetes Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040379
American Medical Association (AMA)
Chen, Jui-Ming& Chang, Cheng-Wei& Lin, Ying-Chieh& Horng, Jorng-Tzong& Sheu, Wayne Huey-Herng. Acarbose Treatment and the Risk of Cardiovascular Disease in Type 2 Diabetic Patients: A Nationwide Seven-Year Follow-Up Study. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040379
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040379