Pathological and ultrastructural studies anisakis simplex rudolphi-1809 infecting carangoides bajad with special reference to intestinal maturation in puppies
Joint Authors
Arafa, Salwa Z.
al-Hut, Abd Allah
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 39, Issue 2 (31 Aug. 2009), pp.606-618, 13 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2009-08-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Topics
Abstract EN
A total of 120 albino mice were divided into: Gl (80 infected with S.
manso-ni cercariae by tail immersion) and G2 (40 uninfected controls).
Seven weeks after infection, Gl was subdivided into four subgroups of 20 mice each.
Gla: Infected untreated control.
Gib: treated with Praziquantel (PZQ) in a dose of 500 mg/kg for two consecutive days.
Glc: treated with Oltipraz (Oz) in a dose of 500 mg/kg for three consecutive days.
Gld: treated with combination of PZQ and Oz (1/3 therapeutic dose of both for two consecutive days.
G2 was divided into 4 subgroups of ten mice each.
G2a: non infected non treated.
G2b: PZQ treated (PZQ control positive).
G2c: Oz treated (Oz control positive).
G2d: Drugs treated (PZQ and Oz control positive).
The effect of drugs was done 2 weeks post-treatment, parasitological to detect number of worms and the distribution in liver vasculature after perfusion of hepatic circulation of mice, and number of eggs per gram of liver tissue.
Al¬so, histopathological examination of liver samples with H& E and/or Masson's trachoma stains showed effect on granuloma and tissue.
PZQ gave reduction of .
total worm burden to 0.22 +0.01 (99%), while Oz gave 22.4+0.57 (3.6%).
PZQ produced marked hepatic shift while Oz gave 6.14%efficacy.
A decrease in egg number with PZQ was 63.69%.
Oz gave 13.5%.
Complete disappearance of immature ova with increase no.
of dead ones was 97.89% of mature ova stage to 2.11% after PZQ.
Oz gave 45% of all detected ova with slight increase of dead ones to 14.18% compared to 9.8% in infected control.
Improvement of hepatic pathology in form of 51.2% reduction in granuloma size and 54.7% decrease in number with improvement of hepatocytes was after treatment with PZQ in contrary to Oz as reduction of size and number of granulorpa was 13.6% and 21.6% respectively.
Combination of reduced dose of both drugs produced moderate effect on all criteria less than that detected with full dose of PZQ, but much better that obtained after Oz.
American Psychological Association (APA)
Arafa, Salwa Z.& al-Hut, Abd Allah. 2009. Pathological and ultrastructural studies anisakis simplex rudolphi-1809 infecting carangoides bajad with special reference to intestinal maturation in puppies. Journal of the Egyptian Society of Parasitology،Vol. 39, no. 2, pp.606-618.
https://search.emarefa.net/detail/BIM-104081
Modern Language Association (MLA)
Arafa, Salwa Z.& al-Hut, Abd Allah. Pathological and ultrastructural studies anisakis simplex rudolphi-1809 infecting carangoides bajad with special reference to intestinal maturation in puppies. Journal of the Egyptian Society of Parasitology Vol. 39, no. 2 (Aug. 2009), pp.606-618.
https://search.emarefa.net/detail/BIM-104081
American Medical Association (AMA)
Arafa, Salwa Z.& al-Hut, Abd Allah. Pathological and ultrastructural studies anisakis simplex rudolphi-1809 infecting carangoides bajad with special reference to intestinal maturation in puppies. Journal of the Egyptian Society of Parasitology. 2009. Vol. 39, no. 2, pp.606-618.
https://search.emarefa.net/detail/BIM-104081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 613-616
Record ID
BIM-104081