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Fabrication and In Vitro Evaluation of Nanosized HydroxyapatiteChitosan-Based Tissue Engineering Scaffolds
Joint Authors
Sultana, Naznin
Khan, Tareef Hayat
Sun, Tao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Composite scaffolds based on biodegradable natural polymer and osteoconductive hydroxyapatite (HA) nanoparticles can be promising for a variety of tissue engineering (TE) applications.
This study addressed the fabrication of three-dimensional (3D) porous composite scaffolds composed of HA and chitosan fabricated via thermally induced phase separation and freeze-drying technique.
The scaffolds produced were subsequently characterized in terms of microstructure, porosity, and mechanical property.
In vitro degradation and in vitro biological evaluation were also investigated.
The scaffolds were highly porous and had interconnected pore structures.
The pore sizes ranged from several microns to a few hundred microns.
The incorporated HA nanoparticles were well mixed and physically coexisted with chitosan in composite scaffold structures.
The addition of 10% (w/w) HA nanoparticles to chitosan enhanced the compressive mechanical properties of composite scaffold compared to pure chitosan scaffold.
In vitro degradation results in phosphate buffered saline (PBS) showed slower uptake properties of composite scaffolds.
Moreover, the scaffolds showed positive response to mouse fibroblast L929 cells attachment.
Overall, the findings suggest that HA/chitosan composite scaffolds could be suitable for TE applications.
American Psychological Association (APA)
Sun, Tao& Khan, Tareef Hayat& Sultana, Naznin. 2014. Fabrication and In Vitro Evaluation of Nanosized HydroxyapatiteChitosan-Based Tissue Engineering Scaffolds. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1041266
Modern Language Association (MLA)
Sun, Tao…[et al.]. Fabrication and In Vitro Evaluation of Nanosized HydroxyapatiteChitosan-Based Tissue Engineering Scaffolds. Journal of Nanomaterials No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1041266
American Medical Association (AMA)
Sun, Tao& Khan, Tareef Hayat& Sultana, Naznin. Fabrication and In Vitro Evaluation of Nanosized HydroxyapatiteChitosan-Based Tissue Engineering Scaffolds. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1041266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041266