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A Comparative Study of Bioartificial Bone Tissue Poly-L-lactic AcidPolycaprolactone and PLLA Scaffolds Applied in Bone Regeneration
Joint Authors
Weng, Weizong
Song, Shaojun
Cao, Liehu
Chen, Xiao
Cai, Yuanqi
Li, Haihang
Zhou, Qirong
Zhang, Jun
Su, Jiacan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Bioartificial bone tissue engineering is an increasingly popular technique to repair bone defect caused by injury or disease.
This study aimed to investigate the feasibility of PLLA/PCL (poly-L-lactic acid/polycaprolactone) by a comparison study of PLLA/PCL and PLLA scaffolds applied in bone regeneration.
Thirty healthy mature New Zealand rabbits on which 15 mm distal ulna defect model had been established were selected and then were divided into three groups randomly: group A (repaired with PLLA scaffold), group B (repaired with PLLA/PCL scaffold), and group C (no scaffold) to evaluate the bone-remodeling ability of the implants.
Micro-CT examination revealed the prime bone regeneration ability of group B in three groups.
Bone mineral density of surgical site in group B was higher than group A but lower than group C.
Meanwhile, the bone regeneration in both groups A and B proceeded with signs of inflammation for the initial fast degradation of scaffolds.
As a whole, PLLA/PCL scaffolds in vivo initially degrade fast and were better suited to repair bone defect than PLLA in New Zealand rabbits.
Furthermore, for the low mineral density of new bone and rapid degradation of the scaffolds, more researches were necessary to optimize the composite for bone regeneration.
American Psychological Association (APA)
Weng, Weizong& Song, Shaojun& Cao, Liehu& Chen, Xiao& Cai, Yuanqi& Li, Haihang…[et al.]. 2014. A Comparative Study of Bioartificial Bone Tissue Poly-L-lactic AcidPolycaprolactone and PLLA Scaffolds Applied in Bone Regeneration. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042056
Modern Language Association (MLA)
Weng, Weizong…[et al.]. A Comparative Study of Bioartificial Bone Tissue Poly-L-lactic AcidPolycaprolactone and PLLA Scaffolds Applied in Bone Regeneration. Journal of Nanomaterials No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042056
American Medical Association (AMA)
Weng, Weizong& Song, Shaojun& Cao, Liehu& Chen, Xiao& Cai, Yuanqi& Li, Haihang…[et al.]. A Comparative Study of Bioartificial Bone Tissue Poly-L-lactic AcidPolycaprolactone and PLLA Scaffolds Applied in Bone Regeneration. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042056