![](/images/graphics-bg.png)
Evaluation of Corneal Topography and Biomechanical Parameters after Use of Systemic Isotretinoin in Acne Vulgaris
Joint Authors
Demirok, Ahmet
Yildirim, Yusuf
Olcucu, Onur
Alagoz, Cengiz
Demircan, Ali
Basci, Abdurrahman
Kutlubay, Zekayi
Agca, Alper
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
We report the effect of isotretinoin on corneal topography, corneal thickness, and biomechanical parameters in patients with acne vulgaris.
Method.
Fifty-four eyes of 54 patients who received oral isotretinoin for treatment of acne vulgaris were evaluated.
All patients underwent a corneal topographical evaluation with a Scheimpflug camera combined with Placido-disk (Sirius), ultrasonic pachymetry measurements, and corneal biomechanical evaluation with an ocular response analyzer at baseline, in the 1st, 3rd, and 6th months of treatment, and 6 months after isotretinoin discontinuation.
Results.
The thinnest corneal thickness measured with Sirius differed significantly in the 1st, 3rd, and 6th months compared with the baseline measurement; there was no significant change in ultrasonic central corneal thickness measurements and biomechanical parameters (corneal hysteresis and corneal resistance factor) throughout the study.
Average simulated keratometry and surface asymmetry index increased significantly only in the first month of treatment according to the baseline.
All changes disappeared 6 months after the end of treatment.
Conclusion.
Basal tear secretion and corneal morphologic properties were significantly influenced during the systemic isotretinoin treatment and the changes were reversible after discontinuation.
No statistical important biomechanical differences were found to be induced by isotretinoin.
American Psychological Association (APA)
Yildirim, Yusuf& Olcucu, Onur& Agca, Alper& Alagoz, Cengiz& Demircan, Ali& Basci, Abdurrahman…[et al.]. 2014. Evaluation of Corneal Topography and Biomechanical Parameters after Use of Systemic Isotretinoin in Acne Vulgaris. Journal of Ophthalmology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042597
Modern Language Association (MLA)
Yildirim, Yusuf…[et al.]. Evaluation of Corneal Topography and Biomechanical Parameters after Use of Systemic Isotretinoin in Acne Vulgaris. Journal of Ophthalmology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1042597
American Medical Association (AMA)
Yildirim, Yusuf& Olcucu, Onur& Agca, Alper& Alagoz, Cengiz& Demircan, Ali& Basci, Abdurrahman…[et al.]. Evaluation of Corneal Topography and Biomechanical Parameters after Use of Systemic Isotretinoin in Acne Vulgaris. Journal of Ophthalmology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042597