Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury?

Joint Authors

Sabour, Hadis
Norouzi Javidan, Abbas
Latifi, Sahar
Hadian, Mohammad Reza
Emami Razavi, Seyed-Hassan
Shidfar, Farzad
Vafa, Mohammad Reza
Aghaei Meybodi, Hamidreza

Source

Journal of Osteoporosis

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-08-21

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Diseases
Medicine

Abstract EN

Purpose.

The association between serum lipids and bone mineral density (BMD) has been investigated previously but, up to now, these relationships have not yet been described in spinal cord injury (SCI).

We tried to assess the correlation between serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) and BMD in male subjects with SCI.

Methods.

Dual-energy X-ray absorptiometry (DXA) was used to assess BMD in femoral neck, trochanter, intertrochanteric zone, and lumbar vertebras.

Blood samples were taken to measure serums lipids and bone biomarkers including osteocalcin, cross-linked type I collagen (CTX), and bone alkaline phosphatase (BALP).

Partial correlation analysis was used to evaluate the relationships between mentioned measurements after adjustment for weight and age.

Results.

We found a positive correlation between HDL and femoral neck BMD ( P : 0.004, r = 0.33 ).

HDL was negatively correlated with osteocalcin ( P : 0.017, r = - 0.31 ) which was not in consistency with its relationship with BMD.

TC and LDL were not related to CTX, BALP and BMD.

Conclusion.

This study does not support a strong association between serum lipids and BMD in subjects with SCI.

Moreover it seems that positive association between HDL and BMD is not mediated through increased bone formation.

American Psychological Association (APA)

Sabour, Hadis& Norouzi Javidan, Abbas& Latifi, Sahar& Hadian, Mohammad Reza& Emami Razavi, Seyed-Hassan& Shidfar, Farzad…[et al.]. 2014. Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury?. Journal of Osteoporosis،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042704

Modern Language Association (MLA)

Sabour, Hadis…[et al.]. Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury?. Journal of Osteoporosis No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1042704

American Medical Association (AMA)

Sabour, Hadis& Norouzi Javidan, Abbas& Latifi, Sahar& Hadian, Mohammad Reza& Emami Razavi, Seyed-Hassan& Shidfar, Farzad…[et al.]. Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury?. Journal of Osteoporosis. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042704

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1042704