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Effects of Short Term Exposure of Atrazine on the Liver and Kidney of Normal and Diabetic Rats
Joint Authors
Jestadi, Dinesh Babu
Phaniendra, Alugoju
Babji, Undru
Srinu, Thupakula
Shanmuganathan, Bhavatharini
Periyasamy, Latha
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present study evaluates the effects of short term (15 days) exposure of low dose (300 μg kg−1) of atrazine (2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine) on antioxidant status and markers of liver and kidney damage in normal (nondiabetic) and diabetic male Wistar rats.
Rats were divided into four groups: Group I as normal control, Group II as atrazine treated, Group III as diabetic control, and Group IV as atrazine treated diabetic rats.
Atrazine administration resulted in increased MDA concentration as well as increased activities of SOD, CAT, and GPx in both liver and kidney of atrazine treated and atrazine treated diabetic rats.
However, GSH level was decreased in both liver and kidney of atrazine treated and atrazine treated diabetic rats.
Atrazine administration led to significant increase in liver damage biomarkers such as AST, ALT, and ALP as well as kidney damage biomarkers such as creatinine and urea in both normal and diabetic rats, but this increase was more pronounced in diabetic rats when compared to normal rats.
In conclusion, the results of the present study demonstrate that short term exposure of atrazine at a dose of 300 μg kg−1 could potentially induce oxidative damage in liver and kidney of both normal and diabetic rats.
American Psychological Association (APA)
Jestadi, Dinesh Babu& Phaniendra, Alugoju& Babji, Undru& Srinu, Thupakula& Shanmuganathan, Bhavatharini& Periyasamy, Latha. 2014. Effects of Short Term Exposure of Atrazine on the Liver and Kidney of Normal and Diabetic Rats. Journal of Toxicology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043200
Modern Language Association (MLA)
Jestadi, Dinesh Babu…[et al.]. Effects of Short Term Exposure of Atrazine on the Liver and Kidney of Normal and Diabetic Rats. Journal of Toxicology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043200
American Medical Association (AMA)
Jestadi, Dinesh Babu& Phaniendra, Alugoju& Babji, Undru& Srinu, Thupakula& Shanmuganathan, Bhavatharini& Periyasamy, Latha. Effects of Short Term Exposure of Atrazine on the Liver and Kidney of Normal and Diabetic Rats. Journal of Toxicology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043200