Association between TSH-Receptor Autoimmunity, Hyperthyroidism, Goitre, and Orbitopathy in 208 Patients Included in the Remission Induction and Sustenance in Graves’ Disease Study
Joint Authors
Andersen, Stine Linding
Laurberg, Peter
Nygaard, Birte
Andersen, Stig
Carlé, Allan
Karmisholt, Jesper
Krejbjerg, Anne
Pedersen, Inge Bülow
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Graves’ disease may have a number of clinical manifestations with varying degrees of activity that may not always run in parallel.
Objectives.
To study associations between serum levels of TSH-receptor autoantibodies and the three main manifestations of Graves’ disease (hyperthyroidism, goiter, and presence of orbitopathy) at the time of diagnosis of hyperthyroidism.
Methods.
We describe a cohort of 208 patients with newly diagnosed Graves’ hyperthyroidism.
Patients were enrolled in a multiphase study of antithyroid drug therapy of Graves’ hyperthyroidism, entitled “Remission Induction and Sustenance in Graves’ Disease (RISG).” Patients were systematically tested for degree of biochemical hyperthyroidism, enlarged thyroid volume by ultrasonography, and the presence of orbitopathy.
Results.
Positive correlations were found between the levels of TSH-receptor autoantibodies in serum and the three manifestations of Graves’ disease: severeness of hyperthyroidism, presence of enlarged thyroid, and presence of orbitopathy, as well as between the different types of manifestations.
Only around half of patients had enlarged thyroid gland at the time of diagnosis of hyperthyroidism, whereas 25–30% had orbitopathy.
Conclusions.
A positive but rather weak correlation was found between TSH-receptor antibodies in serum and the major clinical manifestation of Graves’ disease.
Only half of the patients had an enlarged thyroid gland at the time of diagnosis.
American Psychological Association (APA)
Laurberg, Peter& Nygaard, Birte& Andersen, Stig& Carlé, Allan& Karmisholt, Jesper& Krejbjerg, Anne…[et al.]. 2014. Association between TSH-Receptor Autoimmunity, Hyperthyroidism, Goitre, and Orbitopathy in 208 Patients Included in the Remission Induction and Sustenance in Graves’ Disease Study. Journal of Thyroid Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043256
Modern Language Association (MLA)
Laurberg, Peter…[et al.]. Association between TSH-Receptor Autoimmunity, Hyperthyroidism, Goitre, and Orbitopathy in 208 Patients Included in the Remission Induction and Sustenance in Graves’ Disease Study. Journal of Thyroid Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1043256
American Medical Association (AMA)
Laurberg, Peter& Nygaard, Birte& Andersen, Stig& Carlé, Allan& Karmisholt, Jesper& Krejbjerg, Anne…[et al.]. Association between TSH-Receptor Autoimmunity, Hyperthyroidism, Goitre, and Orbitopathy in 208 Patients Included in the Remission Induction and Sustenance in Graves’ Disease Study. Journal of Thyroid Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043256
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043256