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Stress-Induced Mast Cell Activation in Glabrous and Hairy Skin
Joint Authors
Căruntu, Constantin
Boda, Daniel
Musat, Sorin
Căruntu, Ana
Mandache, Eugen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mast cells play a key role in modulation of stress-induced cutaneous inflammation.
In this study we investigate the impact of repeated exposure to stress on mast cell degranulation, in both hairy and glabrous skin.
Adult male Wistar rats were randomly divided into four groups: Stress 1 day ( n = 8 ) , Stress 10 days ( n = 7 ) , Stress 21 days ( n = 6 ) , and Control ( n = 8 ) .
Rats in the stress groups were subjected to 2 h/day restraint stress.
Subsequently, glabrous and hairy skin samples from animals of all groups were collected to assess mast cell degranulation by histochemistry and transmission electron microscopy.
The impact of stress on mast cell degranulation was different depending on the type of skin and duration of stress exposure.
Short-term stress exposure induced an amplification of mast cell degranulation in hairy skin that was maintained after prolonged exposure to stress.
In glabrous skin, even though acute stress exposure had a profound stimulating effect on mast cell degranulation, it diminished progressively with long-term exposure to stress.
The results of our study reinforce the view that mast cells are active players in modulating skin responses to stress and contribute to further understanding of pathophysiological mechanisms involved in stress-induced initiation or exacerbation of cutaneous inflammatory processes.
American Psychological Association (APA)
Căruntu, Constantin& Boda, Daniel& Musat, Sorin& Căruntu, Ana& Mandache, Eugen. 2014. Stress-Induced Mast Cell Activation in Glabrous and Hairy Skin. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043310
Modern Language Association (MLA)
Căruntu, Constantin…[et al.]. Stress-Induced Mast Cell Activation in Glabrous and Hairy Skin. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043310
American Medical Association (AMA)
Căruntu, Constantin& Boda, Daniel& Musat, Sorin& Căruntu, Ana& Mandache, Eugen. Stress-Induced Mast Cell Activation in Glabrous and Hairy Skin. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043310
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043310